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PRI-724

Cat. No. M10678
PRI-724 Structure
Synonym:

C-82 prodrug; ICG-001 analog

Size Price Availability Quantity
10mg USD 450  USD450 In stock
25mg USD 810  USD810 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

PRI-724 (C-82 prodrug, ICG-001 analog) is a potent, specific inhibitor that disrupts the interaction of β-catenin and CBP.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 658.64
Formula C33H35N6O7P
CAS Number 1422253-38-0
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] Silvia Schmidtova, et al. Int J Mol Sci. Targeting of Deregulated Wnt/β-Catenin Signaling by PRI-724 and LGK974 Inhibitors in Germ Cell Tumor Cell Lines

[2] Ryosuke Gabata, et al. Anticancer Res. Anti-tumor Activity of the Small Molecule Inhibitor PRI-724 Against β-Catenin-activated Hepatocellular Carcinoma

[3] Hiroyasu Okazaki, et al. Exp Lung Res. The novel inhibitor PRI-724 for Wnt/β-catenin/CBP signaling ameliorates bleomycin-induced pulmonary fibrosis in mice

[4] Masaru Katoh. Int J Mol Med. Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review)

[5] Masaru Katoh. Int J Oncol. Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review)

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Keywords: PRI-724, C-82 prodrug; ICG-001 analog supplier, Wnt/beta-catenin, inhibitors

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