| Cat.No. | Name | Information |
|---|---|---|
| M2008 | ICG-001 | ICG-001 is a novel small molecule inhibitor of TCF/beta-catenin-mediated transcription. ICG-001 specifically binds to cyclic AMP response element-binding protein with an IC50 of 3 μM. |
| M1796 | XAV939 | XAV939 is a potent, cell-permeable small molecule inhibitor of the Wnt/β-catenin pathway to TNKS1 and TNKS2 with IC50 values of 11 and 4 nM respectively. |
| M2781 | IWP-L6 | IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM. |
| M2237 | IWP-2 | IWP-2 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 27 nM. |
| M2782 | IWR-1-endo | IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. |
| M9790 | BML-284 | BML-284 (Wnt agonist 1) is a potent and selective activator of Wnt signaling. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM. |
| M30048 | Pamidronic acid | Pamidronic acid is a agent used to treat a broad spectrum of bone absorption diseases. |
| M29742 | ZW4864 | ZW4864 is an orally active and selective β catenin/B-Cell lymphoma 9 protein−protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM. |
| M29741 | ZW4864 free base | ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein−protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 (free base) inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM. |
| M29676 | Miclxin | Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex. |
| M29346 | FzM1.8 | FzM1.8 derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K. |
| M29240 | DK419 | DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK. |
| M28962 | iCRT-5 | iCRT-5 is a β-catenin-regulated transcription (CRT) inhibitor. iCRT-5 can block Wnt/β-catenin reporter activity and down regulate β-catenin expression. iCRT-5 can be used for the research of multiple myeloma. |
| M28404 | Teplinovivint | Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor. Teplinovivint has anti-inflammatory activity and has the potential for tendinopathy research. |
| M28379 | UU-T01 | UU-T01 is a selective inhibitor for β-Catenin/T-cell factor 4 protein-protein interaction (β-catenin/Tcf PPI) with an Ki value of 3.14 µM. UU-T01 is directly combined with β-catenin, and the KD value is 0.531 µM. |
| M28247 | Dalosirvat | Dalosirvat (Wnt pathway activator 1) is a potent Wnt activator, with an EC50s of 28-29 nM. |
| M24733 | Tabituximab barzuxetan | Tabituximab barzuxetan (OTSA101-DTPA-90Y) is a radioimmunoconjugate composed of a humanized monoclonal antibody targeting FZD-10 (OTSA-101), and labeled with Yttrium 90. Tabituximab barzuxetan shows antineoplastic activity. Tabituximab barzuxetan can be used for synovial sarcoma research. |
| M24643 | Ipafricept | Ipafricept (OMP-54F28; FZD8-Fc) is a first-in-class recombinant fusion protein consisting of an extracellular portion of the human frizzled 8 receptor fused to a fragment of human IgG1 Fc that binds Wnt ligand.Ipafricept has solid tumor inhibitory activity and is well tolerated. |
| M7879 | Toxoflavin (Xanthothricin) | Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor and antibiotic activity. |
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