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2-Hydroxycinnamaldehyde

Cat. No. M39854
2-Hydroxycinnamaldehyde Structure
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Biological Activity

2-Hydroxycinnamaldehyde is a phenylpropanoid that can be isolated from the bark of Cinnamomum cassia. 2-Hydroxycinnamaldehyde inhibits Wnt/β-catenin, STAT3 signaling. 2-Hydroxycinnamaldehyde induces cell apoptosis 2-Hydroxycinnamaldehyde has antitumor and anti-inflammation activities.

Chemical Information
Molecular Weight 148.16
Formula C9H8O2
CAS Number 3541-42-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kyung-Sook Chung et al. Pharmaceutics. Regulation of ROS-Dependent JNK Pathway by 2'-Hydroxycinnamaldehyde Inducing Apoptosis in Human Promyelocytic HL-60 Leukemia Cells

[2] Lihua Hao et al. Exp Mol Med. 2'-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice

[3] Yae Jin Yoon et al. Cancer Lett. 2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2

[4] Hai-Anh Nguyen et al. Int J Oncol. 2'-Hydroxycinnamaldehyde induces apoptosis through HSF1-mediated BAG3 expression

[5] Ismail Ahmed Ismail et al. Breast Cancer Res Treat. 2-Hydroxycinnamaldehyde inhibits the epithelial-mesenchymal transition in breast cancer cells

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Keywords: 2-Hydroxycinnamaldehyde supplier, Wnt/beta-catenin, inhibitors, activators

 
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