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BML-284

Cat. No. M9790
BML-284 Structure
Synonym:

Wnt agonist 1; AMBMP

Size Price Availability Quantity
5mg USD 61.2  USD68 In stock
10mg USD 81  USD90 In stock
25mg USD 180  USD200 In stock
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Quality Control
Biological Activity

BML-284 (Wnt agonist 1) is a potent and selective activator of Wnt signaling. BML-284 enhances beta-catenin and increases transcript and protein levels of p-gp. BML-284 increases the migration and invasion of both MNK45 and AGS cells and partially restores the migratory and invasive abilities of cells inhibited by pizotifen. BML-284 induces the expression of β-catenin significantly when compared with the NC group.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 350.37
Formula C19H18N4O3
CAS Number 853220-52-7
Purity >99%
Solubility DMSO ≥ 30 mg/mL
Storage at -20°C
References

Exposure to Oxadiazon-Butachlor causes cardiac toxicity in zebrafish embryos
Yong Huang, et al. Environ Pollut. 2020 Oct;265(Pt A):114775. PMID: 32504889.

AOC4P suppresses viability and invasion and induces apoptosis in NSCLC cells by inhibiting the Wnt/β-catenin pathway
Fengbo Li, et al. Chem Biol Interact. 2020 Jul 1;325:109110. PMID: 32325081.

Differential Effects of Small Molecule WNT Agonists on the Multilineage Differentiation Capacity of Human Mesenchymal Stem Cells
Roberto Narcisi, et al. Tissue Eng Part A. 2016 Nov;22(21-22):1264-1273. PMID: 27633010.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BML-284, Wnt agonist 1; AMBMP supplier, Wnt/beta-catenin, inhibitors

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