BML-284 (Wnt agonist 1) is a potent and selective activator of Wnt signaling. BML-284 enhances beta-catenin and increases transcript and protein levels of p-gp. BML-284 increases the migration and invasion of both MNK45 and AGS cells and partially restores the migratory and invasive abilities of cells inhibited by pizotifen. BML-284 induces the expression of β-catenin significantly when compared with the NC group.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||DMSO ≥ 30 mg/mL|
Exposure to Oxadiazon-Butachlor causes cardiac toxicity in zebrafish embryos
Yong Huang, et al. Environ Pollut. 2020 Oct;265(Pt A):114775. PMID: 32504889.
AOC4P suppresses viability and invasion and induces apoptosis in NSCLC cells by inhibiting the Wnt/β-catenin pathway
Fengbo Li, et al. Chem Biol Interact. 2020 Jul 1;325:109110. PMID: 32325081.
Differential Effects of Small Molecule WNT Agonists on the Multilineage Differentiation Capacity of Human Mesenchymal Stem Cells
Roberto Narcisi, et al. Tissue Eng Part A. 2016 Nov;22(21-22):1264-1273. PMID: 27633010.
|Related Wnt/beta-catenin Products|
FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM.
SKL2001 is a novel agonist of Wnt/β-catenin pathway with anti-cancer activity.
Adavivint (SM04690) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter.
Gallocyanine is a small molecule DKK1 inhibitor, which blocks DKK1 inhibitory activity on Wnt signaling.
Berberine is an alkaloid in several plants with various biological functions, including insulin-sensitizing, anti-inflammatory, and anti-oxidant activity.
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