| Cat.No. | Name | Information |
|---|---|---|
| M2008 | ICG-001 | ICG-001 is a novel small molecule inhibitor of TCF/beta-catenin-mediated transcription. ICG-001 specifically binds to cyclic AMP response element-binding protein with an IC50 of 3 μM. |
| M1796 | XAV939 | XAV939 is a potent, cell-permeable small molecule inhibitor of the Wnt/β-catenin pathway to TNKS1 and TNKS2 with IC50 values of 11 and 4 nM respectively. |
| M2781 | IWP-L6 | IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM. |
| M2237 | IWP-2 | IWP-2 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 27 nM. |
| M2782 | IWR-1-endo | IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. |
| M9790 | BML-284 | BML-284 (Wnt agonist 1) is a potent and selective activator of Wnt signaling. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM. |
| M58606 | (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide | (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide is a macamide isolated from Maca (Lepidium meyenii Walp). (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide induces mesenchymal stem cells osteogenic differentiation and consequent bone formation through activating the canonical Wnt/β‐catenin signaling pathway. |
| M58586 | UU-T02 | UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction, with a Ki of 1.36 μM. UU-T02 inhibits canonical Wnt signaling. |
| M58585 | Wnt/β-catenin agonist 1 | Wnt/β-catenin agonist 1 is a Wnt/β-catenin signalling pathway agonist, with an EC50 of 0.27 μM. |
| M57233 | CGK012 | CKG012 is an inhibitor for Wnt/βcatenin signaling pathway. |
| M57230 | exo-IWR-1 | exo-IWR-1, an inactive stereoisomer of Endo-IWR-1, is a negative control of IWR-1. |
| M50388 | FZD7 antagonist 1 | FZD7 antagonist 1 (peptide 34) is a dFz7-21 analogue. |
| M43577 | β-Catenin modulator-1 | β-Catenin modulator-1 (IIa-650) is a β-Catenin modulator useful in cancer research. |
| M43576 | β-Catenin modulator-5 | β-Catenin modulator-5, an oxazole and thiazole compound, is a potent and selective β-Catenin modulator. |
| M43575 | β-Catenin modulator-4 | β-Catenin modulator-4, an oxazole and thiazole compound, is a potent and selective β-Catenin modulator. |
| M43574 | β-Catenin modulator-3 | β-Catenin modulator-3, an oxazole and thiazole compound, is a potent and selective β-Catenin modulator. |
| M43573 | β-Catenin modulator-2 | β-Catenin modulator-2, an oxazole and thiazole compound, is a potent and selective β-Catenin modulator. |
| M43568 | WIC1 | WIC1 is a potent Wnt inhibitor. |
| M43565 | β-catenin-IN-7 | β-catenin-IN-7 is a β-catenin inhibitor. |
| M43564 | 8BTC | 8BTC is a potent covalent Notum inhibitor with IC50 of 2.5 nM. |
| M43563 | Porcn-IN-2 | Porcn-IN-2 is a Wnt inhibitor, with an IC50 value of 0.05 nM. |
| M43562 | Wnt pathway inhibitor 3 | Wnt pathway inhibitor 3 is a potent wnt inhibitor with an IC50 value of 45 nM. |
| M43561 | YW2036 | YW2036 is a potent Wnt/β-Catenin signaling pathway inhibitor with an IC50 value of 637 nM. |
| M41380 | NSC260594 | NSC260594 induces Apoptosis. |
| M39854 | 2-Hydroxycinnamaldehyde | 2-Hydroxycinnamaldehyde is a phenylpropanoid that can be isolated from the bark of Cinnamomum cassia. 2-Hydroxycinnamaldehyde inhibits Wnt/β-catenin, STAT3 signaling. 2-Hydroxycinnamaldehyde induces cell apoptosis 2-Hydroxycinnamaldehyde has antitumor and anti-inflammation activities. |
| M30259 | (E)-Ferulic acid | (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. |
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