| Cat.No. | Name | Information |
|---|---|---|
| M2008 | ICG-001 | ICG-001 is a novel small molecule inhibitor of TCF/beta-catenin-mediated transcription. |
| M1796 | XAV939 | XAV939 is a potent, cell-permeable small molecule inhibitor of the Wnt/β-catenin pathway to TNKS1 and TNKS2 with IC50 values of 11 and 4 nM respectively. |
| M2781 | IWP-L6 | IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM. |
| M2237 | IWP-2 | IWP-2 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 27 nM. |
| M2782 | IWR-1-endo | IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. |
| M9790 | BML-284 | BML-284 (Wnt agonist 1) is a potent and selective activator of Wnt signaling. |
| M43575 | β-Catenin modulator-4 | β-Catenin modulator-4, an oxazole and thiazole compound, is a potent and selective β-Catenin modulator. |
| M43574 | β-Catenin modulator-3 | β-Catenin modulator-3, an oxazole and thiazole compound, is a potent and selective β-Catenin modulator. |
| M43573 | β-Catenin modulator-2 | β-Catenin modulator-2, an oxazole and thiazole compound, is a potent and selective β-Catenin modulator. |
| M43568 | WIC1 | WIC1 is a potent Wnt inhibitor. |
| M43567 | Box5 | Box5 is a potent Wnt5a antagonist. |
| M43565 | β-catenin-IN-7 | β-catenin-IN-7 is a β-catenin inhibitor. |
| M43564 | 8BTC | 8BTC is a potent covalent Notum inhibitor with IC50 of 2.5 nM. |
| M43563 | Porcn-IN-2 | Porcn-IN-2 is a Wnt inhibitor, with an IC50 value of 0.05 nM. |
| M43562 | Wnt pathway inhibitor 3 | Wnt pathway inhibitor 3 is a potent wnt inhibitor with an IC50 value of 45 nM. |
| M43561 | YW2036 | YW2036 is a potent Wnt/β-Catenin signaling pathway inhibitor with an IC50 value of 637 nM. |
| M41380 | NSC260594 | NSC260594 induces Apoptosis. |
| M39854 | 2-Hydroxycinnamaldehyde | 2-Hydroxycinnamaldehyde is a phenylpropanoid that can be isolated from the bark of Cinnamomum cassia. 2-Hydroxycinnamaldehyde inhibits Wnt/β-catenin, STAT3 signaling. 2-Hydroxycinnamaldehyde induces cell apoptosis 2-Hydroxycinnamaldehyde has antitumor and anti-inflammation activities. |
| M30259 | (E)-Ferulic acid | (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. |
| M30048 | Pamidronic acid | Pamidronic acid is a agent used to treat a broad spectrum of bone absorption diseases. |
| M29742 | ZW4864 | ZW4864 is an orally active and selective β catenin/B-Cell lymphoma 9 protein−protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM. |
| M29741 | ZW4864 free base | ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein−protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 (free base) inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM. |
| M29676 | Miclxin | Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex. |
| M29514 | ABC99 | ABC99 is an N-hydroxyhydantoin (NHH) carbamate that selectively inhibits the Wnt-deacylating enzyme NOTUM (IC50=13 nM). ABC99 preserves Wnt3A signaling in the presence of NOTUM. |
| M29346 | FzM1.8 | FzM1.8 derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K. |
| M29240 | DK419 | DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK. |
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