| Cat.No. | Name | Information |
|---|---|---|
| M2008 | ICG-001 | ICG-001 is a novel small molecule inhibitor of TCF/beta-catenin-mediated transcription. ICG-001 specifically binds to cyclic AMP response element-binding protein with an IC50 of 3 μM. |
| M1796 | XAV939 | XAV939 is a potent, cell-permeable small molecule inhibitor of the Wnt/β-catenin pathway to TNKS1 and TNKS2 with IC50 values of 11 and 4 nM respectively. |
| M2781 | IWP-L6 | IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM. |
| M2237 | IWP-2 | IWP-2 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 27 nM. |
| M2782 | IWR-1-endo | IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. |
| M9790 | BML-284 | BML-284 (Wnt agonist 1) is a potent and selective activator of Wnt signaling. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM. |
| M8173 | Salinomycin | Salinomycin is a carboxylic polyether ionophore with antibiotic and anti-cancer properties. |
| M7992 | PNU-74654 | PNU-74654 inhibits the Wnt-β catenin pathway by blocking the interaction between β-catenin and TCF (T cell factor). |
| M7024 | Neurodazine | Neurodazin is a compound that induces neurogenesis in mature skeletal muscle cells. |
| M6855 | JW 74 | JW 74 is a wnt pathway inhibitor, with an IC50 of 420 nM. JW 74 targets the β-catenin destruction complex (GSK-3 beta /AXIN/APC). JW 74 increases AXIN2 and decreases active β-catenin levels in colorectal cancer (CRC) cells. |
| M6854 | JW 67 | JW 67 is a wnt pathway inhibitor; induces degradation of active β-catenin. |
| M6839 | IWP 4 | IWP 4 is a potent inhibitor of Wnt/β-catenin signaling. |
| M6835 | IQ 1 | IQ 1 is a enables Wnt/β-catenin-driven expansion of ESCs; prevents spontaneous differentiation. |
| M6813 | iCRT 14 | iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT), with IC50 of 40.3 nM against Wnt responsive STF16 luciferase. |
| M5261 | CP21R7 | CP21R7, also known CP21, is a potent and selective GSK-3β inhibitor that can potently activate canonical Wnt signalling. |
| M4866 | LF3 | LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM. |
| M4829 | WIKI4 | WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM) that inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM). |
| M4632 | Xanthatin | Xanthatin has antibacterial and antifungal activies against MRSA. Xanthatin can inhibit murine melanoma B16-F1 cell proliferation possibly associated with activation of Wnt/β-catenin pathway and its activity against melanoma tumor might also be relevant to inhibition of angiogenesis. |
| M4452 | Echinacoside | Echinacoside is a phenylethanol compound isolated from Cistanche salsa that effectively inhibits the Wnt/β-catenin signaling pathway. Echinacoside plays a neuroprotective role by activating Trk receptors and their downstream signaling pathways. Echinacoside also has significant anti-osteoporosis activity. |
| M4197 | Triptonide | Triptonide (NSC 165677) is a natural product identified from Triptonia wilfordii. Triptonide is a Wnt signaling inhibitor with an IC50 of about 0.3 nM. Triptonide has immunosuppressive, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects. |
| M4038 | Astragaloside-I | Astragaloside I is a natural compound isolated from astragalus. Astragaloside I has osteogenic activity by stimulating osteoblast differentiation through the Wnt/β-catenin signaling pathway. |
| M4003 | Isoquercitrin | Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway. Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. |
| M3886 | WAY-262611 | WAY-262611 is a Wnt pathway agonist acting via inhibition of Dkk1 with no GSK-3β inhibition and the TCF-Luciferase EC50=0.63µM. |
| M3131 | Wnt-C59 | Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM. |
| M2877 | Nefopam hydrochloride | Nefopam hydrochloride is an centrally-acting but non-opioid analgesic compound by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake. |
| M2812 | LGK-974 | LGK-974 (WNT-974) is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM. |
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