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Triptonide

Cat. No. M4197

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Triptonide Structure
Synonym:

NSC 165677; PG 492

Size Price Availability Quantity
1mg USD 80  USD80 In stock
5mg USD 170  USD170 In stock
10mg USD 250  USD250 In stock
20mg USD 330  USD330 In stock
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Quality Control & Documentation
Biological Activity

Triptonide (NSC 165677) is a natural product identified from Triptonia wilfordii. Triptonide is a Wnt signaling inhibitor with an IC50 of about 0.3 nM. Triptonide has immunosuppressive, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects.

Chemical Information
Molecular Weight 358.39
Formula C20H22O6
CAS Number 38647-11-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Mengli Zhang, et al. Triptonide effectively inhibits triple-negative breast cancer metastasis through concurrent degradation of Twist1 and Notch1 oncoproteins

[2] Zongliang Chang, et al. Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates

[3] Bowen Gao, et al. Identification of triptonide as a therapeutic agent for triple negative breast cancer treatment

[4] Xiaoning Zhang, et al. lncRNA involved in triptonide-induced cytotoxicity in mouse germ cells

[5] Mengli Zhang, et al. Triptonide inhibits lung cancer cell tumorigenicity by selectively attenuating the Shh-Gli1 signaling pathway

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Keywords: Triptonide, NSC 165677; PG 492 supplier, Wnt/beta-catenin, inhibitors, activators

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