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Triptonide

Cat. No. M4197
Triptonide Structure
Synonym:

NSC 165677; PG 492

Size Price Availability Quantity
20mg USD 300  USD300 In stock
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Quality Control & Documentation
Biological Activity

Triptonide (NSC 165677) is a natural product identified from Triptonia wilfordii. Triptonide is a Wnt signaling inhibitor with an IC50 of about 0.3 nM. Triptonide has immunosuppressive, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects.

Chemical Information
Molecular Weight 358.39
Formula C20H22O6
CAS Number 38647-11-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mengli Zhang, et al. Triptonide effectively inhibits triple-negative breast cancer metastasis through concurrent degradation of Twist1 and Notch1 oncoproteins

[2] Zongliang Chang, et al. Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates

[3] Bowen Gao, et al. Identification of triptonide as a therapeutic agent for triple negative breast cancer treatment

[4] Xiaoning Zhang, et al. lncRNA involved in triptonide-induced cytotoxicity in mouse germ cells

[5] Mengli Zhang, et al. Triptonide inhibits lung cancer cell tumorigenicity by selectively attenuating the Shh-Gli1 signaling pathway

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Keywords: Triptonide, NSC 165677; PG 492 supplier, Wnt/beta-catenin, inhibitors, activators


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