Wnt-C59

Cat. No. M3131

All AbMole products are for research use only, cannot be used for human consumption.

Synonym:

C59

Size	Price	Availability
2mg	USD 40 USD40	In stock
5mg	USD 55 USD55	In stock
10mg	USD 85 USD85	In stock

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Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM.

	Source	Stem Cells Transl Med (2016). Figure 4. Wnt-C59
	Method	qPCR
	Cell Lines	human iPSCs
	Concentrations	10 nM
	Incubation Time	4 or 5 days
	Results	qPCR analyses revealed that neural aggregates differentiated with C59 contained more cells with rostral identity compared with DKK1 or XAV

Cell Experiment
Cell lines	NMuMG (NMG) and MDA-MB 231 cells
Preparation method	Cells are seeded at a concentration of 4×10³/well in 100 μL culture medium containing various amouts of Wnt-C59 and incubated for 48 hours at 37 ℃. Add 10 μL/well cell proliferation reagent and incubate for 4 hours at 37 ℃. Shake thoroughly for 1 min on a shaker. Measure the absorbance of the samples in a microplate (ELISA) reader.
Concentrations
Incubation time	48 hours

Animal Experiment
Animal models	Female nude mice orthotopically transplanted with independent MMTV-WNT1 tumors
Formulation	0.5% methylcellulose and 0.1% Tween-80
Dosages	10 mg/kg
Administration	orally

Molecular Weight	379.45
Formula	C25H21N3O
CAS Number	1243243-89-1
Solubility (25°C)	DMSO 56 mg/mL
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

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