Salinomycin produced by Streptomyces albus is a carboxylic polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma. Salinomycin inhibits multidrug resistance protein 1 and induces apoptosis by the generation of reactive oxygen species that cause DNA damage and inactivation of Stat3. Use of salinomycin as antibiotic results in lowered spermatozoa count and motility and decreased steroidogenesis in mice.
| Molecular Weight | 751 |
| Formula | C42H70O11 |
| CAS Number | 53003-10-4 |
| Solubility (25°C) | DMSO: ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Wnt/beta-catenin Products |
|---|
| β-Catenin modulator-1
β-Catenin modulator-1 (IIa-650) is a β-Catenin modulator useful in cancer research. |
| β-Catenin modulator-5
β-Catenin modulator-5, an oxazole and thiazole compound, is a potent and selective β-Catenin modulator. |
| β-Catenin modulator-4
β-Catenin modulator-4, an oxazole and thiazole compound, is a potent and selective β-Catenin modulator. |
| β-Catenin modulator-3
β-Catenin modulator-3, an oxazole and thiazole compound, is a potent and selective β-Catenin modulator. |
| β-Catenin modulator-2
β-Catenin modulator-2, an oxazole and thiazole compound, is a potent and selective β-Catenin modulator. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
