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Salinomycin

Cat. No. M8173

All AbMole products are for research use only, cannot be used for human consumption.

Salinomycin Structure
Synonym:

Procoxacin

Size Price Availability Quantity
5mg USD 85  USD85 In stock
10mg USD 145  USD145 In stock
50mg USD 470  USD470 In stock
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Quality Control & Documentation
Biological Activity

Salinomycin produced by Streptomyces albus is a carboxylic polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma. Salinomycin inhibits multidrug resistance protein 1 and induces apoptosis by the generation of reactive oxygen species that cause DNA damage and inactivation of Stat3. Use of salinomycin as antibiotic results in lowered spermatozoa count and motility and decreased steroidogenesis in mice.

Chemical Information
Molecular Weight 751
Formula C42H70O11
CAS Number 53003-10-4
Solubility (25°C) DMSO: ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Lu D, et al. Proc Natl Acad Sci U S A. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells.

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Keywords: Salinomycin, Procoxacin supplier, Wnt/beta-catenin, inhibitors, activators

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