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Xanthatin

Cat. No. M4632
Xanthatin Structure
Size Price Availability Quantity
5mg USD 360  USD400 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Xanthatin has antibacterial and antifungal activies against MRSA. Xanthatin can inhibit murine melanoma B16-F1 cell proliferation possibly associated with activation of Wnt/β-catenin pathway and its activity against melanoma tumor might also be relevant to inhibition of angiogenesis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 246.3
Formula C15H18O3
CAS Number 26791-73-1
Purity >99%
Solubility DMSO
Storage at -20°C
References

Optimization of xanthatin extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties
M Romero, et al. Eur J Med Chem. 2015 Jan 27;90:491-6. PMID: 25481815.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Xanthatin supplier, Wnt/beta-catenin, inhibitors

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