CP21R7 can inhibitor enhances the induction of KDR+precursors prior to vascular commitment.Cp21R7 compound induced the highest luciferase activity at a concentration of 3 μ M. Immunofluorescence staining revealed that CP21 significantly increased total levels of intracellular -catenin. Activation of WNT signaling via GSK3 inhibition with CP21 induced commitment of hPSCs towards mesoderm.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||63 mg/mL in DMSO|
Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells.
Sahara M, et al. Cell Res. 2015 Jan;25(1):148. PMID: 25553820.
Vaccination with vascular progenitor cells derived from induced pluripotent stem cells elicits antitumor immunity targeting vascular and tumor cells.
Koido S, et al. Cancer Immunol Immunother. 2014 May;63(5):459-68. PMID: 24627093.
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