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JW 74

Cat. No. M6855
JW 74 Structure
Size Price Availability
5mg USD 90  USD100 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

JW 74 is a inhibitor of canonical Wnt signaling. JW 74 targets the β-catenin destruction complex (GSK-3 beta /AXIN/APC). JW 74 increases AXIN2 and decreases active β-catenin levels in colorectal cancer (CRC) cells. JW 74 also arrests cell cycle in G1 and inhibits proliferation of CRC cells in vitro. JW 74 inhibits tumor growth and formation in mouse models.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 456.52
Formula C24H20N6O2S
CAS Number 863405-60-1
Purity >98%
Solubility DMSO 45 mg/mL
Storage at -20°C
References

Apigen induces apoptosis through a mitochondria/caspase-pathway in human breast cancer MDA-MB-453 cells.
Choi, et al. J Clin Biochem Nutr. 2009;44: 260. PMID: 19430615.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: JW 74 supplier, Wnt/beta-catenin, inhibitors

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