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iCRT 14 is a potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between β-catenin and TCF4. iCRT 14 induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.
| Molecular Weight | 375.44 |
| Formula | C21H17N3O2S |
| CAS Number | 677331-12-3 |
| Solubility (25°C) | DMSO 28 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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