Free shipping on all orders over $ 500

WAY-262611

Cat. No. M3886
WAY-262611 Structure
Size Price Availability Quantity
5mg USD 72  USD80 In stock
10mg USD 108  USD120 In stock
25mg USD 189  USD210 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

WAY262611 was able to enhance trabecular bone formation rate in the tibia of OVX rats following oral administration. WAY-262611 is acting via the Wnt β-catenin pathway and most likely through inhibition of Dkk-1.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 318.42
Formula C20H22N4
CAS Number 1123231-07-1
Purity 99.43%
Solubility DMSO 38 mg/mL
Storage at -20°C
References

(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate.
Pelletier JC, et al. J Med Chem. 2009 Nov 26;52(22):6962-5. PMID: 19856966.

Related Wnt/beta-catenin Products
FIDAS-5

FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM.

BML-284

BML-284 (Wnt agonist 1) is a potent and selective activator of Wnt signaling.

SKL2001

SKL2001 is a novel agonist of Wnt/β-catenin pathway with anti-cancer activity.

Adavivint

Adavivint (SM04690) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter.

Gallocyanine

Gallocyanine is a small molecule DKK1 inhibitor, which blocks DKK1 inhibitory activity on Wnt signaling.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: WAY-262611 supplier, Wnt/beta-catenin, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.