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Methyl vanillate

Cat. No. M10996
Methyl vanillate  Structure
Size Price Availability Quantity
500mg USD 50  USD50 In stock
1g USD 60  USD60 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Methyl vanillate, an extract found in the genus Loquat, is a Wnt/β-catenin signaling pathway activator. Benzoate, is the methyl ester of vanillin. It has antioxidant effects. Plant metabolites.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 182.17
Formula C9H10O4
CAS Number 3943-74-6
Purity >99%
Solubility DMSO ≥ 20 mg/mL
Storage at -20°C
References

[1] Stefania Di Lella, et al. Phytochem Anal. White rot fungal impact on the evolution of simple phenols during decay of silver fir wood by UHPLC-HQOMS

[2] Delong Jiao, et al. ACS Biomater Sci Eng. Synergistic Osteogenesis of Biocompatible Reduced Graphene Oxide with Methyl Vanillate in BMSCs

[3] Sue Ji Lim, et al. J Pharm Pharmacol. Effects of Hovenia dulcis Thunb. extract and methyl vanillate on atopic dermatitis-like skin lesions and TNF-α/IFN-γ-induced chemokines production in HaCaT cells

[4] Antonella Tosti, et al. J Cosmet Dermatol. Topical application of the Wnt/β-catenin activator methyl vanillate increases hair count and hair mass index in women with androgenetic alopecia

[5] Pu-Hyeon Cha, et al. PLoS One. Hovenia dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice

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Keywords: Methyl vanillate supplier, Wnt/beta-catenin, inhibitors

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