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Cinobufotalin

Cat. No. M11484
Cinobufotalin Structure
Size Price Availability Quantity
10mg USD 186  USD186 In stock
20mg USD 345  USD345 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Cinobufotalin is a cardiotonic steroid, or butadienolide, derived from the skin secretions of toads. SREBP1 is a novel inhibitor that inhibits the proliferation of hepatocellular carcinoma by targeting adipogenesis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 458.54
Formula C26H34O7
CAS Number 1108-68-5
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage 2-8°C
References

[1] Cong Li, et al. Prog Brain Res. Network pharmacological mechanism of Cinobufotalin against glioma

[2] Youxi Han, et al. Evid Based Complement Alternat Med. Combined Treatment of Cinobufotalin and Gefitinib Exhibits Potent Efficacy against Lung Cancer

[3] Lin-Lu Li, et al. Evid Based Complement Alternat Med. The Effectiveness and Safety of Cinobufotalin Injection as an Adjunctive Treatment for Lung Cancer: A Meta-Analysis of Randomized Controlled Trials

[4] Min Li, et al. Toxicol Res (Camb). Safety reassessment of cinobufotalin injection: new findings into cardiotoxicity

[5] Huiling Sun, et al. Onco Targets Ther. Cinobufotalin as an effective adjuvant therapy for advanced gastric cancer: a meta-analysis of randomized controlled trials

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