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Gallocyanine

Cat. No. M9417
Gallocyanine Structure
Size Price Availability Quantity
500mg USD 50  USD50 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Gallocyanine is a small molecule DKK1 inhibitor, which blocks DKK1 inhibitory activity on Wnt signaling. Gallocyanine is also used as nuclear dye in staining.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 336.73
Formula C15H13ClN2O5
CAS Number 1562-85-2
Purity >98%
Solubility Ethanol ≥ 15 mM
Storage 2-8°C, dry, protect from light, sealed
References

[1] Wan W, et al. Biomed Res Int. The role of Wnt signaling in the development of Alzheimer s disease: a potential therapeutic target?

[2] Li X, et al. Proc Natl Acad Sci U S A. Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.

[3] Simoneau S, et al. PLoS Pathog. In vitro and in vivo neurotoxicity of prion protein oligomers.

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Keywords: Gallocyanine supplier, Wnt/beta-catenin, inhibitors

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