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ABC99 is an N-hydroxyhydantoin (NHH) carbamate that selectively inhibits the Wnt-deacylating enzyme NOTUM (IC50=13 nM). ABC99 preserves Wnt3A signaling in the presence of NOTUM.
| Molecular Weight | 456.88 |
| Formula | C22H21ClN4O5 |
| CAS Number | 2331255-53-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 25 mg/mL (ultrasonic and heat to 60°C) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Yuguang Zhao, et al. Future Med Chem. Small-molecule inhibitors of carboxylesterase Notum
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