Cryptotanshinone was originally isolated from the dried roots of Salvia militorrhiza, an herb that is used extensively in Asian medicine and that is known to exert beneficial effects on the circulatory system.Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells and the growth of the cells through 96 hours of the treatment.Cryptotanshinone significantly attenuated atherosclerotic plaque formation and enhanced plaque stability in ApoE-/- mice by inhibiting lectin-like oxLDL receptor-1 (LOX-1) and matrix metalloproteinase-9 (MMP-9) expression, as well as inhibiting reactive oxygen species (ROS) generation and nuclear factor- kappa B (NF-κB) activation.In vitro,Cryptotanshinone decreased oxLDL-induced LOX-1 mRNA and protein expression, and thereby, inhibited LOX-1-mediated monocytes adhesion to HUVECs through reducing the expression of adhesion molecules (ICAM-1 and VCAM-1).Cryptotanshinone inhibited NADPH oxidase subunit 4 (NOX4)-mediated ROS generation and consequent activation of NF-κB in HUVECs.
Front Immunol . 2022 Feb 7;13:820685.
The Study on the Regulation of Th Cells by Mesenchymal Stem Cells Through the JAK-STAT Signaling Pathway to Protect Naturally Aged Sepsis Model Rats
Cryptotanshinone purchased from AbMole
Research Square. 2020 Feb 13.
STAT3 signaling pathway could be involved in the progress of cognitive dysfunction caused by ligature-induced periodontitis
Cryptotanshinone purchased from AbMole
Acta Pharmacol Sin. 2019 Dec 17.
Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats.
Cryptotanshinone purchased from AbMole
Cell Experiment | |
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Cell lines | KATO III, DU145, PC3, LNCaP, MDA-MB-231, MDA-MB-468, MDA-MB-453, MCF-7, MCF-10A, HeLa and HCT-116 |
Preparation method | Exposing cells to Cryptotanshinone for 24 or 48 hours. For the determination of cell proliferation, adding the cell proliferation reagent WST-1 and using an ELISA reader to measure WST-1 formazan quantitatively at 450 nm. |
Concentrations | Dissolved in DMSO, final concentrations ~50 μM |
Incubation time | 24 or 48 hours |
Animal Experiment | |
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Animal models | Zucker Diabetic Fatty (ZDF) (male) type 2 diabetic rat, ob/ob mice (C57BL/6J-Lepob), db/db mice (C57BL/KsJ-Leprdb) and male C57BL/6J mice with high-fat diet-induced obesity |
Formulation | Dissolved in 0.1% solution of sodium lauryl sulfate |
Dosages | ~600 mg/kg/day |
Administration | Orally |
Molecular Weight | 296.36 |
Formula | C19H20O3 |
CAS Number | 35825-57-1 |
Solubility (25°C) | DMSO 3 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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