All AbMole products are for research use only, cannot be used for human consumption.
Cryptotanshinone was originally isolated from the dried roots of Salvia militorrhiza, an herb that is used extensively in Asian medicine and that is known to exert beneficial effects on the circulatory system.Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells and the growth of the cells through 96 hours of the treatment.Cryptotanshinone significantly attenuated atherosclerotic plaque formation and enhanced plaque stability in ApoE-/- mice by inhibiting lectin-like oxLDL receptor-1 (LOX-1) and matrix metalloproteinase-9 (MMP-9) expression, as well as inhibiting reactive oxygen species (ROS) generation and nuclear factor- kappa B (NF-κB) activation.In vitro,Cryptotanshinone decreased oxLDL-induced LOX-1 mRNA and protein expression, and thereby, inhibited LOX-1-mediated monocytes adhesion to HUVECs through reducing the expression of adhesion molecules (ICAM-1 and VCAM-1).Cryptotanshinone inhibited NADPH oxidase subunit 4 (NOX4)-mediated ROS generation and consequent activation of NF-κB in HUVECs.
Inflammation. 2023 Oct 7.
Suppression of IRF9 Promotes Osteoclast Differentiation by Decreased Ferroptosis via STAT3 Activation
Cryptotanshinone purchased from AbMole
Front Immunol. 2022 Feb 7;13:820685.
The Study on the Regulation of Th Cells by Mesenchymal Stem Cells Through the JAK-STAT Signaling Pathway to Protect Naturally Aged Sepsis Model Rats
Cryptotanshinone purchased from AbMole
Research Square. 2020 Feb 13.
STAT3 signaling pathway could be involved in the progress of cognitive dysfunction caused by ligature-induced periodontitis
Cryptotanshinone purchased from AbMole
Acta Pharmacol Sin. 2019 Dec 17.
Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats.
Cryptotanshinone purchased from AbMole
 |
Source | Customer experimental result (2018). |
| Method | Western blot & Cell viability assay | |
| Cell Lines | ||
| Concentrations | 20 μmol/L | |
| Incubation Time | 48 h | |
| Results | After treatment with STAT3 inhibitor cryptotanshinone (20 μmol/L) for 48 h, the expression of p-STAT3 and STAT3 was detected by Western blot. Effect on cell viability at 48 h of the STAT3 inhibitor cryptotanshinone is shown on the right. |
| Cell Experiment | |
|---|---|
| Cell lines | KATO III, DU145, PC3, LNCaP, MDA-MB-231, MDA-MB-468, MDA-MB-453, MCF-7, MCF-10A, HeLa and HCT-116 |
| Preparation method | Exposing cells to Cryptotanshinone for 24 or 48 hours. For the determination of cell proliferation, adding the cell proliferation reagent WST-1 and using an ELISA reader to measure WST-1 formazan quantitatively at 450 nm. |
| Concentrations | Dissolved in DMSO, final concentrations ~50 μM |
| Incubation time | 24 or 48 hours |
| Animal Experiment | |
|---|---|
| Animal models | Zucker Diabetic Fatty (ZDF) (male) type 2 diabetic rat, ob/ob mice (C57BL/6J-Lepob), db/db mice (C57BL/KsJ-Leprdb) and male C57BL/6J mice with high-fat diet-induced obesity |
| Formulation | Dissolved in 0.1% solution of sodium lauryl sulfate |
| Dosages | ~600 mg/kg/day |
| Administration | Orally |
| Molecular Weight | 296.36 |
| Formula | C19H20O3 |
| CAS Number | 35825-57-1 |
| Solubility (25°C) | DMSO 3 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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HP590 is an orally active, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC50=27.8 nM; ATP inhibition: IC50=24.7 nM). |
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| HJC0123
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| ODZ10117
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| OPB-111077
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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