Free shipping on all orders over $ 500


Cat. No. M3982
Cryptotanshinone Structure


Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 36  USD40 In stock
10mg USD 45  USD50 In stock
25mg USD 81  USD90 In stock
50mg USD 121.5  USD135 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Cryptotanshinone was originally isolated from the dried roots of Salvia militorrhiza, an herb that is used extensively in Asian medicine and that is known to exert beneficial effects on the circulatory system.Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells and the growth of the cells through 96 hours of the treatment.Cryptotanshinone significantly attenuated atherosclerotic plaque formation and enhanced plaque stability in ApoE-/- mice by inhibiting lectin-like oxLDL receptor-1 (LOX-1) and matrix metalloproteinase-9 (MMP-9) expression, as well as inhibiting reactive oxygen species (ROS) generation and nuclear factor- kappa B (NF-κB) activation.In vitro,Cryptotanshinone decreased oxLDL-induced LOX-1 mRNA and protein expression, and thereby, inhibited LOX-1-mediated monocytes adhesion to HUVECs through reducing the expression of adhesion molecules (ICAM-1 and VCAM-1).Cryptotanshinone inhibited NADPH oxidase subunit 4 (NOX4)-mediated ROS generation and consequent activation of NF-κB in HUVECs.

Product Citations
Customer Product Validations & Biological Datas
Source Customer experimental result (2018).
Method Western blot & Cell viability assay
Cell Lines
Concentrations 20 μmol/L
Incubation Time 48 h
Results After treatment with STAT3 inhibitor cryptotanshinone (20 μmol/L) for 48 h, the expression of p-STAT3 and STAT3 was detected by Western blot. Effect on cell viability at 48 h of the STAT3 inhibitor cryptotanshinone is shown on the right.
Cell Experiment
Cell lines KATO III, DU145, PC3, LNCaP, MDA-MB-231, MDA-MB-468, MDA-MB-453, MCF-7, MCF-10A, HeLa and HCT-116
Preparation method Exposing cells to Cryptotanshinone for 24 or 48 hours. For the determination of cell proliferation, adding the cell proliferation reagent WST-1 and using an ELISA reader to measure WST-1 formazan quantitatively at 450 nm.
Concentrations Dissolved in DMSO, final concentrations ~50 μM
Incubation time 24 or 48 hours
Animal Experiment
Animal models Zucker Diabetic Fatty (ZDF) (male) type 2 diabetic rat, ob/ob mice (C57BL/6J-Lepob), db/db mice (C57BL/KsJ-Leprdb) and male C57BL/6J mice with high-fat diet-induced obesity
Formulation Dissolved in 0.1% solution of sodium lauryl sulfate
Dosages ~600 mg/kg/day
Administration Orally
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 296.36
Formula C19H20O3
CAS Number 35825-57-1
Purity >98%
Solubility DMSO 3 mg/mL
Storage at -20°C

Cryptotanshinone, an orally bioactive herbal compound from Danshen, attenuates atherosclerosis in Apolipoprotein E-Deficient Mice: role of LOX-1.
Liu Z, et al. Br J Pharmacol. 2015 Jan 9. PMID: 25572313.

Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells.
Shin DS, et al. Cancer Res. 2009 Jan 1;69(1):193-202. PMID: 19118003.

Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase.
Kim EJ, et al. Mol Pharmacol. 2007 Jul;72(1):62-72. PMID: 17429005.

Related STAT Products

Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3.


BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor with IC50 of 6.8 μM.

Colivelin TFA

Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3.


STAT5-IN-1 is a cell permeable nonpetidic nicotinoyl hydrazone which suppresses Stat5 via binding to the SH2 domain, with an IC50 of 47 μM for STAT5β isoform.


C188-9 is a small-molecule STAT3 inhibitor, can block Th2 and Th17 cell expansion and cytokine production to prevent house dust mite (HDM)-induced airway inflammation and remodeling.

Abmole Inhibitor Catalog 2017

Keywords: Cryptotanshinone, CTS supplier, STAT, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.