About 30 results found for searched term "STAT" (0.002 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1670 | Belinostat | HDAC |
| PXD101; PX105684 | ||
| Belinostat (PXD101) is a novel HDAC inhibitor with an IC50 of 27 nM. | ||
| M1708 | Selisistat | Sirtuin |
| EX 527; SEN0014196 | ||
| Selisistat (EX 527) is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 98 nM. | ||
| M1711 | Febuxostat (TEI-6720) | Xanthine Oxidase |
| TEI-6720; Uloric; TMX-67 | ||
| Febuxostat (TEI-6720) is a non-purine selective xanthine oxidase inhibitor with IC50 of 114 -210 nM. | ||
| M1726 | FG-4592 (Roxadustat) | HIF |
| Roxadustat; ASP1517 | ||
| FG-4592 (Roxadustat; ASP1517) is a novel Hypoxia Inducible Factor Prolyl Hydroxylase inhibitor. | ||
| M1730 | Givinostat hydrochloride monohydrate | HDAC |
| ITF-2357 hydrochloride monohydrate | ||
| ITF2357 (Givinostat, Gavinostat) is a histone deacetylase inhibitor. The IC50 values for maize HDAC preparations HD2, HD-1B and HD-1A are 10, 7.5 and 16 nM respectively. | ||
| M1748 | LBH589 (Panobinostat) | HDAC |
| NVP-LBH589, Panobinostat | ||
| LBH589 (Panobinostat) is a novel broad-spectrum HDAC inhibitor for MOLT-4 and Reh cells with IC50 of 5 and 20 nM, respectively. | ||
| M1753 | Trichostatin A | HDAC |
| TSA | ||
| Trichostatin A (TSA) is a potent and specific inhibitor of mammalian histone deacetylase (HDAC) class I/II, with an IC50 value of 1.8 nM for HDAC. | ||
| M1775 | Tubastatin A hydrochloride | HDAC |
| Tubastatin A HCl; TSA HCl | ||
| Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 values of 15 nM. | ||
| M1778 | SB939 | HDAC |
| Pracinostat | ||
| SB939 is a novel potent and orally active histone deacetylase with high tumor exposure and efficacy in mouse models of colorectal cancer. | ||
| M1780 | Vorinostat | HDAC |
| SAHA; Zolinza; MK-0683; Suberoylanilide hydroxamic acid | ||
| Vorinostat (SAHA, Zolinza, MK-0683) is a selective and potent histone deacetylase (HDAC) inhibitor with the IC50 value of 10 nM for HDAC-1. | ||
| M1790 | MGCD0103 | HDAC |
| Mocetinostat | ||
| MGCD0103 is a novel HDAC inhibitor, highly specific for classes I and IV HDACs, with IC50 of 0.15, 0.29 and 1.66 μM for HDAC 1, HDAC 2 and HDAC 3 respectively. | ||
| M1791 | Entinostat (MS-275) | HDAC |
| SNDX-275, MS-27-275 | ||
| Entinostat (MS-275) is an oral and selective class I HDAC inhibitor, with IC50s of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3, respectively. | ||
| M1813 | PCI-24781 | HDAC |
| Abexinostat; CRA-024781 | ||
| PCI-24781 is a novel and potent histone deacetylase (HDAC) inhibitor with IC50 value of 0.43 to 2.7 μM. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M9217 | Givinostat | HDAC |
| ITF2357 | ||
| Givinostat (ITF-2357) is an HDAC inhibitor with IC50s of 198 and 157 nM for HDAC1 and HDAC3, respectively. | ||
| M1883 | Ubenimex | Aminopeptidase |
| Bestatin | ||
| Ubenimex, also known as bestatin, is a competitive protease inhibitor. | ||
| M1910 | Nepicastat hydrochloride | Dopamine Receptor |
| SYN117 | ||
| Nepicastat hydrochloride is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respectively. | ||
| M1947 | BMS-708163 | Gamma-secretase/Beta-secretase |
| Avagacestat | ||
| BMS-708163 (Avagacestat) is a selective γ-secretase inhibitor (IC50 = 0.3 nM). | ||
| M1993 | Droxinostat | HDAC |
| NS 41080 | ||
| Droxinostat is a selective inhibitor of HDAC3, HDAC6 and HDAC8 with IC50 of 16.9 μM, 2.47μM and 1.46 μM, respectively. | ||
| M2111 | Fimepinostat | HDAC |
| CUDC-907 | ||
| Fimepinostat (CUDC-907) is a potent, orally-available small molecule dual PI3K and HDAC inhibitor, with IC50 values of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10, respectively. | ||
| M2349 | (R)-Nepicastat hydrochloride | HCV Protease |
| RS-25560-198 HCl | ||
| (R)-Nepicastat hydrochloride, the R-enantiomer of Nepicastat hydrochloride, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. | ||
| M2119 | JNJ-26481585 | HDAC |
| Quisinostat | ||
| JNJ-26481585 (Quisinostat) is a novel second-generation class I HDAC inhibitor. | ||
| M2123 | Rocilinostat | HDAC |
| ACY-1215; Ricolinostat | ||
| Rocilinostat (ACY-1215) is an HDAC6-selective inhibitor with IC50 of 5 nM. | ||
| M2126 | Fluvastatin sodium | HMG-CoA Reductase |
| XU 62-320 | ||
| Fluvastatin sodium is an orally active, potent and competitive HMG-CoA reductase inhibitor with IC50 value between 40 and 100 nM at human liver microsomes. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. | ||
| M2147 | Ilomastat | MMP |
| GM6001; Galardin | ||
| Ilomastat (GM6001; Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor with Ki values of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM and 0.36 nM for MMPs -1, -2, -3, -7, -8, -9, -12, -14 and -26, respectively. Ilomastat (GM6001; Galardin) reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. | ||
| M2179 | EPZ-5676 | Histone Methyltransferase |
| Pinometostat | ||
| EPZ-5676 is a potent and selective aminonucleoside inhibitor of DOT1L histone methyltransferase. | ||
| M2189 | Pevonedistat | NEDD8-activating Enzyme |
| MLN4924; MLN-4924 | ||
| Pevonedistat (MLN4924) is a first-of-its-kind (first-in-class) small molecule inhibitor of Nedd8 activating enzyme (NAE) with an IC50 of 4.7 nM. | ||
| M2274 | Fosbretabulin disodium | Microtubule |
| Combretastatin A-4 phosphate, CA4P | ||
| Fosbretabulin disodium (Combretastatin A-4 phosphate) is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM. | ||
| M2277 | Semagacestat | Gamma-secretase/Beta-secretase |
| LY450139 | ||
| Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. | ||
| M2283 | Rosuvastatin calcium | HMG-CoA Reductase |
| Crestor; ZD 4522 Calcium | ||
| Rosuvastatin (Crestor) is a member of statins and used to treat high cholesterol and related conditions. | ||
| M2284 | Tosedostat | Aminopeptidase |
| CHR2797 | ||
| CHR-2797 is an aminopeptidase inhibitor for LAP, PuSA and Aminopeptidase N with IC50 of 100 nM, 150 nM and 220 nM, respectively. | ||
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