About 30 results found for searched term "STAT" (0.002 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1670 | Belinostat | HDAC |
| PXD101; PX105684 | ||
| Belinostat (PXD101) is a novel HDAC inhibitor with an IC50 of 27 nM. | ||
| M1708 | Selisistat (EX 527) | Sirtuin |
| SEN0014196; Selisistat | ||
| Selisistat (EX 527) is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 98 nM. | ||
| M1711 | Febuxostat (TEI-6720) | Xanthine Oxidase |
| TEI-6720; Uloric; TMX-67 | ||
| Febuxostat (TEI-6720) is a non-purine selective xanthine oxidase inhibitor with IC50 of 114 -210 nM. | ||
| M1726 | FG-4592 (Roxadustat) | HIF |
| Roxadustat; ASP1517 | ||
| FG-4592 (Roxadustat; ASP1517) is a novel Hypoxia Inducible Factor Prolyl Hydroxylase inhibitor. | ||
| M1730 | Givinostat hydrochloride monohydrate | HDAC |
| ITF-2357 hydrochloride monohydrate | ||
| ITF2357 (Givinostat, Gavinostat) is a histone deacetylase inhibitor. The IC50 values for maize HDAC preparations HD2, HD-1B and HD-1A are 10, 7.5 and 16 nM respectively. | ||
| M1748 | LBH589 (Panobinostat) | HDAC |
| NVP-LBH589, Panobinostat | ||
| LBH589 (Panobinostat) is a novel broad-spectrum HDAC inhibitor for MOLT-4 and Reh cells with IC50 of 5 and 20 nM, respectively. | ||
| M1753 | Trichostatin A | HDAC |
| TSA | ||
| Trichostatin A (TSA) is a potent, reversible inhibitor of mammalian histone deacetylase (HDAC) with IC50 value around 20 nM. | ||
| M1775 | Tubastatin A hydrochloride | HDAC |
| Tubastatin A HCl; TSA HCl | ||
| Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 values of 15 nM. | ||
| M1778 | SB939 | HDAC |
| Pracinostat | ||
| SB939 is a novel potent and orally active histone deacetylase with high tumor exposure and efficacy in mouse models of colorectal cancer. | ||
| M1780 | Vorinostat | HDAC |
| SAHA; Zolinza; MK-0683; Suberoylanilide hydroxamic acid | ||
| Vorinostat (SAHA, Zolinza, MK-0683) is a selective and potent histone deacetylase (HDAC) inhibitor with the IC50 value of 10 nM for HDAC-1. | ||
| M1790 | MGCD0103 | HDAC |
| Mocetinostat | ||
| MGCD0103 is a novel HDAC inhibitor, highly specific for classes I and IV HDACs, with IC50 of 0.15, 0.29 and 1.66 μM for HDAC 1, HDAC 2 and HDAC 3 respectively. | ||
| M1791 | Entinostat (MS-275) | HDAC |
| SNDX-275, MS-27-275 | ||
| Entinostat (MS-275) is an oral and selective class I HDAC inhibitor, with IC50s of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3, respectively. | ||
| M1813 | PCI-24781 | HDAC |
| Abexinostat; CRA-024781 | ||
| PCI-24781 is a novel and potent histone deacetylase (HDAC) inhibitor with IC50 value of 0.43 to 2.7 μM. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M9217 | Givinostat | HDAC |
| ITF2357 | ||
| Givinostat (ITF-2357) is an HDAC inhibitor with IC50s of 198 and 157 nM for HDAC1 and HDAC3, respectively. | ||
| M1883 | Ubenimex | Aminopeptidase |
| Bestatin | ||
| Ubenimex, also known as bestatin, is a competitive protease inhibitor. | ||
| M1910 | Nepicastat hydrochloride | Dopamine Receptor |
| SYN117 | ||
| Nepicastat hydrochloride is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respectively. | ||
| M1947 | BMS-708163 | Gamma-secretase/Beta-secretase |
| Avagacestat | ||
| BMS-708163 (Avagacestat) is a selective γ-secretase inhibitor (IC50 = 0.3 nM). | ||
| M1993 | Droxinostat | HDAC |
| NS 41080 | ||
| Droxinostat is a selective inhibitor of HDAC3, HDAC6 and HDAC8 with IC50 of 16.9 μM, 2.47μM and 1.46 μM, respectively. | ||
| M2111 | CUDC-907 | HDAC |
| fimepinostat | ||
| CUDC-907 is a potent, orally-available small molecule dual PI3K and HDAC inhibitor. | ||
| M2349 | (R)-Nepicastat hydrochloride | HCV Protease |
| RS-25560-198 HCl | ||
| (R)-Nepicastat hydrochloride, the R-enantiomer of Nepicastat hydrochloride, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. | ||
| M2119 | JNJ-26481585 | HDAC |
| Quisinostat | ||
| JNJ-26481585 (Quisinostat) is a novel second-generation class I HDAC inhibitor. | ||
| M2123 | Rocilinostat | HDAC |
| ACY-1215; Ricolinostat | ||
| Rocilinostat (ACY-1215) is an HDAC6-selective inhibitor with IC50 of 5 nM. | ||
| M2126 | Fluvastatin sodium | HMG-CoA Reductase |
| XU 62-320 | ||
| Fluvastatin sodium is an orally active, potent and competitive HMG-CoA reductase inhibitor with IC50 value between 40 and 100 nM at human liver microsomes. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. | ||
| M2179 | EPZ-5676 | Histone Methyltransferase |
| Pinometostat | ||
| EPZ-5676 is a potent and selective aminonucleoside inhibitor of DOT1L histone methyltransferase. | ||
| M2189 | Pevonedistat (MLN4924) | NEDD8-activating Enzyme |
| MLN-4924; MLN 4924; Pevonedistat | ||
| Pevonedistat (MLN4924) is a first-of-its-kind (first-in-class) small molecule inhibitor of Nedd8 activating enzyme (NAE) with an IC50 of 4 nM. | ||
| M2274 | Fosbretabulin disodium | Microtubule |
| Combretastatin A-4 phosphate, CA4P | ||
| Fosbretabulin disodium (Combretastatin A-4 phosphate) is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM. | ||
| M2277 | Semagacestat | Gamma-secretase/Beta-secretase |
| LY450139 | ||
| Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. | ||
| M2283 | Rosuvastatin calcium | HMG-CoA Reductase |
| Crestor; ZD 4522 Calcium | ||
| Rosuvastatin (Crestor) is a member of statins and used to treat high cholesterol and related conditions. | ||
| M2284 | Tosedostat | Aminopeptidase |
| CHR2797 | ||
| CHR-2797 is an aminopeptidase inhibitor for LAP, PuSA and Aminopeptidase N with IC50 of 100 nM, 150 nM and 220 nM, respectively. | ||
| M2297 | Devimistat (CPI-613) | Dehydrogenase |
| Devimistat | ||
| Devimistat (CPI-613) inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase. | ||
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