All AbMole products are for research use only, cannot be used for human consumption.
Ilomastat (GM6001; Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor with Ki values of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM and 0.36 nM for MMPs -1, -2, -3, -7, -8, -9, -12, -14 and -26, respectively. Galardin (GM6001) reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. GM6001 also inhibits human skin fibroblast collagenase (Ki = 0.4 nM). GM6001 (Galardin) treatment also inhibited extracellular signal-regulated kinase (ERK) activation induced by bombesin or LPA. In addition, GM6001 inhibited bombesin- or LPA-induced DNA synthesis in a dose dependent manner, when stimulated by increasing concentrations of bombesin, and when added after bombesin stimulation.
Elife. 2020 Sep 28;9:e56006.
The dynamic interplay between ATP/ADP levels and autophagy sustain neuronal migration in vivo
Ilomastat purchased from AbMole
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Source | Oncotarget (2017). Figure 3. GM6001 |
| Method | RT-PCR | |
| Cell Lines | SCC-9 cells | |
| Concentrations | 10 μM | |
| Incubation Time | 24 h | |
| Results | Suppression of MMP-9 expression by MMP-9 shRNA or GM6001 resulted in a significant reduction of the migration and invasion of CAIX-overexpressing SCC-9 cells |
| Molecular Weight | 388.46 |
| Formula | C20H28N4O4 |
| CAS Number | 142880-36-2 |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related MMP Products |
|---|
| MMP2-IN-1
MMP2-IN-1 is a moderate potenet MMP2 inhibitor with IC50 of 6.8 µM. MMP2-IN-1 exhibits remarkable antiproliferative activity in certain cancer cells by arresting the cell cycle and inducing apoptosis. |
| MMP-9 Inhibitor I
MMP-9 inhibitor I is a cell-permeable, potent, selective, and reversible inhibitor of MMP-9 (IC50 = 5 nM). MMP-9 inhibitor I also inhibits MMP-1 (IC50 = 1.05 µM) and MMP-13 IC50 = 113 nM) at higher concentrations. |
| BPHA
BPHA is a potent and orally active MMP-2, MMP-9 and MMP-14 inhibitor with IC50s of 12 nM, 16 nM and 17 nM, respectively. |
| ONO-4817
ONO-4817 is a potent inhibitor of matrix metalloproteinase (MMP). |
| UK-370106
UK-370106 is a potent and highly selective MMP-3 (IC50 of 23 nM) and MMP-12 (IC50 of 42 nM) inhibitor with >1200-fold higher potency than MMP-1, MMP-2, MMP-9, and MMP-14, and about 100-fold than MMP-13 and MMP-8. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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