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Ubenimex

Cat. No. M1883

All AbMole products are for research use only, cannot be used for human consumption.

Ubenimex Structure
Synonym:

Bestatin

Size Price Availability Quantity
1mg USD 25  USD25 In stock
5mg USD 60  USD60 In stock
10mg USD 80  USD80 In stock
25mg USD 140  USD140 In stock
50mg USD 200  USD200 In stock
100mg USD 300  USD300 In stock
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Quality Control & Documentation
Biological Activity

Ubenimex (Bestatin) is an inhibitor of aminopeptidase B, leukotriene A4 hydrolase, aminopeptidase N (Ki = 0.001 - 90 mM). Ubenimex inhibits enkephalin metabolism and leukotriene A4 hydrolase. Bestatin also inhibits tumor cell proliferation. Bestatin induced cell growth inhibition and phenotypic changes of HL-60 and HL-60R cell lines. In vitro, the upregulation of CD13/aminopeptidase N was found after 1 hr, however, the downregulation was observed after 3 hrs incubation with Ubenimex (Bestatin). On the other hand, the downregulation of CD15 and CD33 was observed after both one and 3 hrs incubation. Ubenimex may also be an effective anti-leukemic agent in vivo.

Product Citations
Customer Product Validations & Biological Datas
Source Nan Fang Yi Ke Da Xue Xue Bao (2020 Oct), Figure 3, Ubenimex (Abmole Bioscience)
Method oral gavage
Cell Lines Japanese white rabbits
Concentrations 8 mg/kg·d
Incubation Time 5 days
Results Compared with those in PM group, the rabbits in group BPM showed significantly reduced LTB4 production in the lungs (P < 0.05), up-regulated cAMP/ PKA and Rap1 signaling pathway activities (P < 0.05), and alleviated lung hyper-permeability and inflammation (P < 0.05).
Chemical Information
Molecular Weight 308.38
Formula C16H24N2O4
CAS Number 58970-76-6
Solubility (25°C) DMSO 3 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Imamura N, et al. Leuk Lymphoma. Effect of ubenimex (Bestatin) on the cell growth and phenotype of HL-60 and HL-60R cell lines: up-and down-regulation of CD13/aminopeptidase N.

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Keywords: Ubenimex, Bestatin supplier, Aminopeptidase, inhibitors, activators

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