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G15 inhibits GPER-mediated proliferation stimulated by 17β-estradiol (E2) in A549 and H1793 cell lines. G15 also inhibits the response of GPER stimulated by E2 and G1 in A549 and H1793 cell lines. G15 (1.46 mg/kg; i.h.; twice a week for 14 weeks) decreases the number of tumor nodules and tumor index increased by the E2 or G1 group in urethane-induced adenocarcinoma mice.
Mol Reprod Dev. 2024 Jun 22.
Estrogen influences the transzonal projection assembly of cumulus-oocyte complexes through G protein-coupled estrogen receptor during goat follicle development
G15 purchased from AbMole
Molecules. 2023 Apr 7.
Study of the Sensing Kinetics of G Protein-Coupled Estrogen Receptor Sensors for Common Estrogens and Estrogen Analogs
G15 purchased from AbMole
Environ Pollut. 2021 Feb 1;270:116051.
Bisphenol AF induces apoptosis via estrogen receptor beta (ERβ) and ROS-ASK1-JNK MAPK pathway in human granulosa cell line KGN
G15 purchased from AbMole
Ecotoxicol Environ Saf. 2021 Jan 15;208:111429.
Bisphenol A induces apoptosis through GPER-dependent activation of the ROS/Ca 2+-ASK1-JNK pathway in human granulosa cell line KGN
G15 purchased from AbMole
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Source | ECOTOX ENVIRON SAFE 2021 Jan. Figure 6. G15 (Abmole Bioscience Inc, Houston, TX, USA) |
| Method | cell culture | |
| Cell Lines | KGN cells | |
| Concentrations | 5 μM | |
| Incubation Time | 1h | |
| Results | We found that G15 (a GPER inhibitor) pretreatment significantly inhibited BPA-induced apoptosis of KGN cells, while MPP (an ERα inhibitor) and PHTPP (an ERβ inhibitor) pretreatment had no significant inhibitory effect on apoptosis |
| Molecular Weight | 370.24 |
| Formula | C19H16BrNO2 |
| CAS Number | 1161002-05-6 |
| Solubility (25°C) | DMSO ≥ 20 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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