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TMRM Perchlorate

Cat. No. M9542
TMRM Perchlorate Structure
Size Price Availability Quantity
5mg USD 135  USD135 In stock
10mg USD 200  USD200 In stock
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Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

TMRM Perchlorate is a cell-permeant cationic lipophilic red fluorescent dye (λex=530 nm, λem=592 nm).

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 500.93
Formula C25H25ClN2O7
CAS Number 115532-50-8
Purity >98.5%
Solubility DMSO ≥ 26 mg/mL
Storage 2-8°C, dry, protect from light, sealed
References

[1] Subir Roy Chowdhury, et al. Biosci Rep. Simultaneous Evaluation of Substrate-Dependent Oxygen Consumption Rates and Mitochondrial Membrane Potential by TMRM and Safranin in Cortical Mitochondria

[2] Andrew Monteith, et al. PLoS One. Imaging of Mitochondrial and Non-Mitochondrial Responses in Cultured Rat Hippocampal Neurons Exposed to Micromolar Concentrations of TMRM

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