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Bay 11-7082

Cat. No. M2040
Bay 11-7082 Structure

Bay 11-7821

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 54  USD60 In stock
5mg USD 48.6  USD54 In stock
10mg USD 63  USD70 In stock
25mg USD 126  USD140 In stock
50mg USD 216  USD240 In stock
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Quality Control
Biological Activity

Bay 11-7082 (Bay 11-7821) is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation. Bay 11-7082 selectively and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of IκB-α without affecting constitutive IκB-α phosphorylation. Bay 11-7082 inhibits the TNF-α-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in human endothelial cells with IC50 values of 5-10 µM. Bay 11-7082 also reversibly activates MAP kinases and stimulates apoptosis. Bay 11-7082 rapidly and efficiently reduced the DNA binding of NF-kappaB in HTLV-I-infected T-cell lines and down-regulated the expression of the antiapoptotic gene, Bcl-x(L), regulated by NF-kappaB, whereas it had little effect on the DNA binding of another transcription factor, AP-1. Furthermore, Bay 11-7082- induced apoptosis of primary ATL cells was more prominent than that of normal peripheral blood mononuclear cells, and apoptosis of these cells was also associated with down-regulation of NF-kappaB activity.

Product Citations
Customer Product Validations & Biological Datas
Source Biochem J (2013). Figure 2. Bay 11-7082
Method immunoblotting
Cell Lines human IL-1R cells
Concentrations 15 μM
Incubation Time 1 h
Results BAY 11-7082 completely suppressed the LPS-stimulated and IL-1-stimulated phosphorylation of the activation loop of IKKβ.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 207.25
Formula C10H9NO2S
CAS Number 19542-67-7
Purity 99.33%
Solubility DMSO 31 mg/mL
Storage at -20°C

The role of Rac1 in the regulation of NF-κB activity, cell proliferation, and cell migration in non-small cell lung carcinoma.
Gastonguay A, et al. Cancer Biol Ther. 2012 Jun;13(8):647-56. PMID: 22549160.

The inhibitor of I kappa B alpha phosphorylation BAY 11-7082 prevents NMDA neurotoxicity in mouse hippocampal slices.
Goffi F, et al. Neurosci Lett. 2005 Apr 4;377(3):147-51. PMID: 15755516.

Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells.
Mori N, et al. Blood. 2002 Sep 1;100(5):1828-34. PMID: 12176906.

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Abmole Inhibitor Catalog 2017

Keywords: Bay 11-7082, Bay 11-7821 supplier, IκB/IKK, inhibitors

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