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IκB/IKK Inhibitor of NF-κB/inhibitor of nuclear factor kappa-B kinase

Inhibitors

Cat.No.  Name Information
M2040 Bay 11-7082 Bay 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation (IC50 ~ 10 μM).
M2300 TPCA-1 TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM.
M2769 IMD 0354 IMD-0354 is an IKKβ inhibitor and blocks IκBα phosphorylation in NF-κB pathway.
M2060 SC-514 SC-514 is a selective and reversible inhibitor of IκB kinase 2 (IKK2) with IC50 of 3-12 μM.
M2432 Bardoxolone Methyl Bardoxolone Methyl is an IKK inhibitor with potent pro-apoptotic and anti-inflammatory activities, as well as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway.
M20338 WAY-388756 WAY-388756 is a IKKb inhibitor.
M20027 WAY-113178 WAY-113178 is a IkB kinase-beta (IKKb) inhibitor.
M14590 MRT67307 MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells.
M14589 IKK-IN-1 IKK-IN-1 is an inhibitor of IKK extracted from patent WO2002024679A1, compound example 18-13.
M14588 IKK 16 hydrochloride IKK 16 hydrochloride is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively.
M14587 TBK1/IKKε-IN-2 TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor.
M14586 GSK8612 GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1.
M14585 Bay 65-1942 hydrochloride Bay 65-1942 hydrochloride is an ATP-competitive and selective IKKβ inhibitor.
M11553 WS3 WS3 is a β cell proliferation inducer, which can promote the β cell proliferation of primary rat and human islets. WS3 can be used in the study of type I diabetes.
M11455 ACHP Hydrochloride ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a potent, selective IKK-β Inhibitor with an IC50 of 8.5 nM.
M9546 TBK1/IKKε-IN-5 TBK1/IKKε-IN-5 (compound 1) is a dual TBK1 and IKKε inhibitor, with IC50 values of 1 nM and 5.6 nM for TBK1 and IKKε, respectively.
M8970 MLN120B MLN120B is a potent and effective, ATP competitive IKKβ inhibitor with IC50 value of 20 μM.
M8961 LY2409881 trihydrochloride LY2409881 trihydrochloride is a potent and selective IKK2 inhibitor with IC50 of 30 nM.
M8952 WS6 WS6 is a novel beta cell proliferation simulator, which promotes β cell proliferation in rodent and human primary islets with EC50 of 0.28 uM(R7T1 cell viability).
M6088 LY2409881 LY2409881 is a novel selective inhibitor of IKK2 with IC50 of 30 nM; IC50 for IKK1 and other common kinases is at least one log higher.
M5338 PS-1145 PS-1145 is a specific IKK inhibitor with IC50 of 88 nM.
M5238 Bardoxolone Bardoxolone is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor.
M5197 Amlexanox Amlexanox is a specific inhibitor of IKKε and TBK1, with an IC50 of approximately 1-2 μM.
M4476 Dehydrocostus-Lactone Dehydrocostus-lactone (DHE) is a natural sesquiterpene lactone, inhibits IKKβ activity, IκBα phosphorylation and degradation, coactivators p300 recruitments and p50/p65 NF-κB nuclear translocation, and their DNA binding activity on COX-2 promoter.
M4388 Rosmarinic-acid Rosmarinic acid (RA, Rosemary acid) is a naturally occurring hydroxylated compound, it has the ability to block complement fixation, inhibit lipoxygenase and cyclooxygenase activity and inhibit the expression of CCL11 and CCR3 by suppressing the IKK-β activity in NF-κB activation signaling.



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