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IκB/IKK Inhibitor of NF-κB/inhibitor of nuclear factor kappa-B kinase

Cat.No.  Name Information
M2769 IMD 0354 IMD-0354 is an IKKβ inhibitor and blocks IκBα phosphorylation in NF-κB pathway.
M2432 Bardoxolone Methyl Bardoxolone Methyl is an IKK inhibitor with potent pro-apoptotic and anti-inflammatory activities, as well as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway.
M2300 TPCA-1 TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM.
M2060 SC-514 SC-514 is a selective and reversible inhibitor of IκB kinase 2 (IKK2) with IC50 of 3-12 μM.
M2040 BAY 11-7082 BAY 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation (IC50 ~ 10 μM). BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively).
M21651 BAY-985 BAY-985 is a highly potent, orally active and selective ATP-competitive dual inhibitor of TBK1 and IKKε with IC50s of 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε, respectively.
M21043 Malachite green Malachite green is a synthetic dyestuff and antimicrobial with potential carcinogenicity.
M14590 MRT67307 MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells.
M14588 IKK 16 hydrochloride IKK 16 hydrochloride is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively.
M14586 GSK8612 GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1.
M14585 Bay 65-1942 hydrochloride Bay 65-1942 hydrochloride is an ATP-competitive and selective IKKβ inhibitor.
M11553 WS3 WS3 is a β cell proliferation inducer, which can promote the β cell proliferation of primary rat and human islets. WS3 can be used in the study of type I diabetes.
M9546 TBK1/IKKε-IN-5 TBK1/IKKε-IN-5 (compound 1) is a dual TBK1 and IKKε inhibitor, with IC50 values of 1 nM and 5.6 nM for TBK1 and IKKε, respectively.
M8970 MLN120B MLN120B is a potent and effective, ATP competitive IKKβ inhibitor with IC50 value of 20 μM.
M8961 LY2409881 trihydrochloride LY2409881 trihydrochloride is a potent and selective IKK2 inhibitor with IC50 of 30 nM.
M8952 WS6 WS6 is a novel beta cell proliferation simulator, which promotes β cell proliferation in rodent and human primary islets with EC50 of 0.28 uM(R7T1 cell viability).
M6766 GS 143 GS 143 is a β-TrCP1 ligase inhibitor.
M6502 BI 605906 BI 605906 is a selective IKKβ inhibitor.
M6180 AZD3264 AZD3264 is a novel IKK2 inhibitor.
M6088 LY2409881 LY2409881 is a novel selective inhibitor of IKK2 with IC50 of 30 nM; IC50 for IKK1 and other common kinases is at least one log higher.

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