All AbMole products are for research use only, cannot be used for human consumption.
TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM.
AAPS PharmSciTech. 2020 Nov 2;21(8):298.
Targeted and Combined TPCA-1-Gold Nanocage Therapy for In Vivo Treatment of Inflammatory Arthritis
TPCA-1 purchased from AbMole
Pharmaceutics. 2019 Mar 25;11(3).
Hyaluronic Acid-Modified and TPCA-1-Loaded Gold Nanocages Alleviate Inflammation.
TPCA-1 purchased from AbMole
 |
Source | AAPS PharmSciTech (2020 Nov), Figure 3, TPCA-1 (Abmole Bioscience Inc. Houston, TX, USA) |
| Method | TPCA-1-treated | |
| Cell Lines | mice | |
| Concentrations | 0.016 mg/kg | |
| Incubation Time | 6 days | |
| Results | AuNCs/T/P and HA-AuNCs/T/P treatment significantly reduced the clinical arthritis score and swelling of the hind paws compared with untreated and TPCA-1-treated mice. |
| Molecular Weight | 279.29 |
| Formula | C12H10FN3O2S |
| CAS Number | 507475-17-4 |
| Solubility (25°C) | DMSO 36 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related IκB/IKK Products |
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| ACHP
ACHP is a selective and orally active IκB kinase inhibitor with IC50 values of 8.5 nM and 250 nM for IKKβ and IKKα, respectively. |
| BMS-066
BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor, with IC50s of 9 nM and 72 nM, respectively. |
| Ainsliadimer A
Ainsliadimer A is a novel guaiacolide sesquiterpene dimer isolated from Ainsliaea macrocephala.Ainsliadimer A can block the NF-κB signaling pathway by binding to IKK α/β, and possesses anti-tumor and anti-inflammatory activities.Meanwhile, Ainsliadimer A can also Ainsliadimer A can also directly target peroxidase 1 and 2 (PRDX1 and PRDX2) and significantly inhibit their enzymatic activities. In addition, Ainsliadimer A can cause mitochondrial dysfunction by altering the permeability of mitochondrial membrane potential, inhibiting mitochondrial respiration and ATP production, inhibiting cell proliferation, promoting cell cycle arrest in G2/M phase, and inducing apoptosis. |
| IKK2-IN-4
IKK2-IN-4 is a potent IKK-2 inhibitor, with an IC50 of 25 nM. |
| MRT67307 dihydrochloride
MRT67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. |
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