Free shipping on all orders over $ 500

TPCA-1

Cat. No. M2300
TPCA-1 Structure
Size Price Availability Quantity
5mg USD 70.2  USD78 In stock
10mg USD 126  USD140 In stock
50mg USD 324  USD360 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM.

Product Citations
Customer Product Validations & Biological Datas
Source AAPS PharmSciTech (2020 Nov), Figure 3, TPCA-1 (Abmole Bioscience Inc. Houston, TX, USA)
Method TPCA-1-treated
Cell Lines mice
Concentrations 0.016 mg/kg
Incubation Time 6 days
Results AuNCs/T/P and HA-AuNCs/T/P treatment significantly reduced the clinical arthritis score and swelling of the hind paws compared with untreated and TPCA-1-treated mice.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 279.29
Formula C12H10FN3O2S
CAS Number 507475-17-4
Purity 98.74%
Solubility DMSO 36 mg/mL
Storage at -20°C
References

Targeted and Combined TPCA-1-Gold Nanocage Therapy for In Vivo Treatment of Inflammatory Arthritis
Ziyi Wang, et al. AAPS PharmSciTech. 2020 Nov 2;21(8):298. PMID: 33140225.

Related IκB/IKK Products
TBK1/IKKε-IN-5

TBK1/IKKε-IN-5 (compound 1) is a dual TBK1 and IKKε inhibitor, with IC50 values of 1 nM and 5.6 nM for TBK1 and IKKε, respectively.

MLN120B

MLN120B is a potent and effective, ATP competitive IKKβ inhibitor with IC50 value of 20 μM.

LY2409881 trihydrochloride

LY2409881 trihydrochloride is a potent and selective IKK2 inhibitor with IC50 of 30 nM.

WS6

WS6 is a novel beta cell proliferation simulator, which promotes β cell proliferation in rodent and human primary islets with EC50 of 0.28 uM(R7T1 cell viability).

LY2409881

LY2409881 is a novel selective inhibitor of IKK2 with IC50 of 30 nM; IC50 for IKK1 and other common kinases is at least one log higher.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: TPCA-1 supplier, IκB/IKK, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.