ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a potent, selective IKK-β Inhibitor with an IC50 of 8.5 nM.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||DMSO ≥ 40 mg/mL|
|Storage||4°C , dry , sealed|
|Related IκB/IKK Products|
WS3 is a β cell proliferation inducer, which can promote the β cell proliferation of primary rat and human islets. WS3 can be used in the study of type I diabetes.
TBK1/IKKε-IN-5 (compound 1) is a dual TBK1 and IKKε inhibitor, with IC50 values of 1 nM and 5.6 nM for TBK1 and IKKε, respectively.
MLN120B is a potent and effective, ATP competitive IKKβ inhibitor with IC50 value of 20 μM.
LY2409881 trihydrochloride is a potent and selective IKK2 inhibitor with IC50 of 30 nM.
WS6 is a novel beta cell proliferation simulator, which promotes β cell proliferation in rodent and human primary islets with EC50 of 0.28 uM(R7T1 cell viability).
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