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ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a potent, selective IKK-β Inhibitor with an IC50 of 8.5 nM.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 400.9018 |
| Formula | C21H25ClN4O2 |
| CAS Number | 406209-26-5 |
| Purity | >99% |
| Solubility | DMSO ≥ 40 mg/mL |
| Storage | 4°C , dry , sealed |
| Related IκB/IKK Products |
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| WS3
WS3 is a β cell proliferation inducer, which can promote the β cell proliferation of primary rat and human islets. WS3 can be used in the study of type I diabetes. |
| TBK1/IKKε-IN-5
TBK1/IKKε-IN-5 (compound 1) is a dual TBK1 and IKKε inhibitor, with IC50 values of 1 nM and 5.6 nM for TBK1 and IKKε, respectively. |
| MLN120B
MLN120B is a potent and effective, ATP competitive IKKβ inhibitor with IC50 value of 20 μM. |
| LY2409881 trihydrochloride
LY2409881 trihydrochloride is a potent and selective IKK2 inhibitor with IC50 of 30 nM. |
| WS6
WS6 is a novel beta cell proliferation simulator, which promotes β cell proliferation in rodent and human primary islets with EC50 of 0.28 uM(R7T1 cell viability). |
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