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ACHP Hydrochloride

Cat. No. M11455
ACHP Hydrochloride Structure
Synonym:

IKK-2 Inhibitor VIII

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a potent, selective IKK-β Inhibitor with an IC50 of 8.5 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 400.9018
Formula C21H25ClN4O2
CAS Number 406209-26-5
Purity >99%
Solubility DMSO ≥ 40 mg/mL
Storage 4°C , dry , sealed
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Keywords: ACHP Hydrochloride, IKK-2 Inhibitor VIII supplier, IκB/IKK, inhibitors

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