| Cat.No. | Name | Information |
|---|---|---|
| M2040 | BAY 11-7082 | BAY 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation (IC50 ~ 10 μM). BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). |
| M2300 | TPCA-1 | TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM. |
| M2769 | IMD 0354 | IMD-0354 is an IKKβ inhibitor and blocks IκBα phosphorylation in NF-κB pathway. |
| M2060 | SC-514 | SC-514 is a selective and reversible inhibitor of IκB kinase 2 (IKK2) with IC50 of 3-12 μM. |
| M2432 | Bardoxolone Methyl | Bardoxolone Methyl is an IKK inhibitor with potent pro-apoptotic and anti-inflammatory activities, as well as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway. |
| M5338 | PS-1145 | PS-1145 is a specific IKK inhibitor with IC50 of 88 nM. |
| M5238 | Bardoxolone | Bardoxolone is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor. |
| M5197 | Amlexanox | Amlexanox is a specific inhibitor of IKKε and TBK1, with an IC50 of approximately 1-2 μM. |
| M4476 | Dehydrocostus-Lactone | Dehydrocostus-lactone (DHE) is a natural sesquiterpene lactone, inhibits IKKβ activity, IκBα phosphorylation and degradation, coactivators p300 recruitments and p50/p65 NF-κB nuclear translocation, and their DNA binding activity on COX-2 promoter. |
| M4388 | Rosmarinic-acid | Rosmarinic acid (RA, Rosemary acid) is a naturally occurring hydroxylated compound, it has the ability to block complement fixation, inhibit lipoxygenase and cyclooxygenase activity and inhibit the expression of CCL11 and CCR3 by suppressing the IKK-β activity in NF-κB activation signaling. |
| M4248 | Schizandrol A | Schizandrol A is A lignan. Schisantherin A inhibits p65-NF-κB translocation into the nucleus by IκBα degradation. |
| M2933 | PHA-408 | PHA-408 is a highly selective and ATP-competitive IKK-2 inhibitor with IC50 of 40 nM. |
| M2768 | IKK-16 | IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. |
| M2462 | BMS-345541 | BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively. |
| M2435 | Bay 11-7085 | BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM. |
| M2336 | BMS-345541 hydrochloride | BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of IKK (IC50 values of 0.3 μM and 4 μM for IKK-2 and IKK-1 respectively). |
| M49740 | BMS-066 | BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor, with IC50s of 9 nM and 72 nM, respectively. |
| M45049 | Ainsliadimer A | Ainsliadimer A is a novel guaiacolide sesquiterpene dimer isolated from Ainsliaea macrocephala.Ainsliadimer A can block the NF-κB signaling pathway by binding to IKK α/β, and possesses anti-tumor and anti-inflammatory activities.Meanwhile, Ainsliadimer A can also Ainsliadimer A can also directly target peroxidase 1 and 2 (PRDX1 and PRDX2) and significantly inhibit their enzymatic activities. In addition, Ainsliadimer A can cause mitochondrial dysfunction by altering the permeability of mitochondrial membrane potential, inhibiting mitochondrial respiration and ATP production, inhibiting cell proliferation, promoting cell cycle arrest in G2/M phase, and inducing apoptosis. |
| M42727 | IKK2-IN-4 | IKK2-IN-4 is a potent IKK-2 inhibitor, with an IC50 of 25 nM. |
| M42726 | MRT67307 dihydrochloride | MRT67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. |
| M39207 | 4′-Hydroxywogonin | 4′-Hydroxywogonin has anti-inflammatory activity via TAK1/IKK/NF-κB, MAPKs and PI3/AKT signaling pathways. 4′-Hydroxywogonin inhibits angiogenesis by disrupting PI3K/AKT signaling. 4′-Hydroxywogonin inhibits cell proliferation and induces apoptosis. |
| M31250 | HPN-01 | HPN-01 is a potent and selective IKK inhibitor, with pIC50 values of 6.4, 7.0 and <4.8 for IKK-α, IKK-β and IKK-ε, respectively. HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, and VEGFR-2. |
| M31066 | (Rac)-PF-184 hydrate | (Rac)-PF-184 hydrate is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC50 of 37 nM. (Rac)-PF-184 hydrate has anti-inflammatory effects. |
| M30095 | IMD-0560 | IMD-0560 is a novel IκB kinase β inhibitor. |
| M28613 | BAY32-5915 | BAY32-5915 is a potent IKKα inhibitor with an IC50 value of 60 nM. BAY32-5915 has not affect Doxorubicin-induced NF-κB activation. |
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