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WS3

Cat. No. M11553
WS3  Structure
Size Price Availability Quantity
10mg USD 85  USD85 In stock
50mg USD 310  USD310 In stock
100mg USD 520  USD520 In stock
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Quality Control
Biological Activity

WS3 is a β cell proliferation inducer, which can promote the β cell proliferation of primary rat and human islets. WS3 can be used in the study of type I diabetes.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 569.58
Formula C28H30F3N7O3
CAS Number 1421227-52-2
Purity 98.69%
Solubility N/A
Storage 2-8°C , dry , sealed
References

[1] Wahid Ali Hamood Altowayti, et al. Ecotoxicol Environ Saf. The adsorptive removal of As (III) using biomass of arsenic resistant Bacillus thuringiensis strain WS3: Characteristics and modelling studies

[2] Ibrahim F Farag, et al. Appl Environ Microbiol. Global Distribution Patterns and Pangenomic Diversity of the Candidate Phylum "Latescibacteria" (WS3)

[3] Shu Min Tan, et al. ACS Appl Mater Interfaces. Bottom-up Electrosynthesis of Highly Active Tungsten Sulfide (WS3-x) Films for Hydrogen Evolution

[4] Noha H Youssef, et al. PLoS One. In Silico Analysis of the Metabolic Potential and Niche Specialization of Candidate Phylum "Latescibacteria" (WS3)

[5] V G Grigoriev, et al. Exp Gerontol. Expression of senescence-induced protein WS3-10 in vivo and in vitro

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