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WS3

Cat. No. M11553
WS3  Structure
Size Price Availability Quantity
10mg USD 85  USD85 In stock
50mg USD 310  USD310 In stock
100mg USD 520  USD520 In stock
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Quality Control & Documentation
Biological Activity

WS3 is a β cell proliferation inducer, which can promote the β cell proliferation of primary rat and human islets. WS3 can be used in the study of type I diabetes.

Chemical Information
Molecular Weight 569.58
Formula C28H30F3N7O3
CAS Number 1421227-52-2
Solubility (25°C) N/A
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wahid Ali Hamood Altowayti, et al. Ecotoxicol Environ Saf. The adsorptive removal of As (III) using biomass of arsenic resistant Bacillus thuringiensis strain WS3: Characteristics and modelling studies

[2] Ibrahim F Farag, et al. Appl Environ Microbiol. Global Distribution Patterns and Pangenomic Diversity of the Candidate Phylum "Latescibacteria" (WS3)

[3] Shu Min Tan, et al. ACS Appl Mater Interfaces. Bottom-up Electrosynthesis of Highly Active Tungsten Sulfide (WS3-x) Films for Hydrogen Evolution

[4] Noha H Youssef, et al. PLoS One. In Silico Analysis of the Metabolic Potential and Niche Specialization of Candidate Phylum "Latescibacteria" (WS3)

[5] V G Grigoriev, et al. Exp Gerontol. Expression of senescence-induced protein WS3-10 in vivo and in vitro

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Keywords: WS3 supplier, IκB/IKK, inhibitors, activators


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