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Cat. No. M8952
WS6 Structure
Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 150  USD150 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

WS6 induced up to 4% of rat β cells to proliferate, with an EC50 of 0.4 μM. In the same format, WS6 also induced 3% of human β cells to proliferate, with a similar potency to the rat β cells. WS6 induced R7T1 proliferation in dose response, with EC50 value of 0.28 μM.

In vivo, WS6 (50 mg/kg p.o.) in RIP-DTA mouse model of β cell ablation ameliorates diabetes, and induces concomitant increases in β cell proliferation and β cell number.

Cell Experiment
Cell lines R7T1 cells
Preparation method R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells.
Concentrations ~10 μM
Incubation time 4 days
Animal Experiment
Animal models
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 568.59
Formula C29H31F3N6O3
CAS Number 1421227-53-3
Purity >98%
Solubility DMSO: ≥ 60 mg/mL
Storage at -20°C

[1] Shen W, et al. J Am Chem Soc. Small-molecule inducer of β cell proliferation identified by high-throughput screening.

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Abmole Inhibitor Catalog 2017

Keywords: WS6 supplier, IκB/IKK, inhibitors

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