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DTT

Cat. No. M9093
DTT Structure
Synonym:

DL-Dithiothreitol; Cleland’s reagent

Size Price Availability Quantity
500mg USD 45  USD50 In stock
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Quality Control
Biological Activity

Dithiothreitol (DTT) is the common name for a small-molecule redox reagent known as Cleland's reagent; as a reducing or "deprotecting" agent for thiolated DNA.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 154.25
Formula C4H10O2S2
CAS Number 3483-12-3
Purity 99.76%
Solubility DMSO: ≥ 75 mg/mL
Water: ≥ 90 mg/mL
Storage 2-8°C, dry, sealed
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  Catalog
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Keywords: DTT, DL-Dithiothreitol; Cleland’s reagent supplier, inhibitors

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