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DTT

Cat. No. M9093
DTT Structure
Synonym:

DL-Dithiothreitol; Cleland’s reagent

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500mg USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

Dithiothreitol (DTT) is the common name for a small-molecule redox reagent known as Cleland's reagent; as a reducing or "deprotecting" agent for thiolated DNA.

Product Citations
Chemical Information
Molecular Weight 154.25
Formula C4H10O2S2
CAS Number 3483-12-3
Solubility (25°C) DMSO: ≥ 75 mg/mL
Water: ≥ 90 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Amber L Kramer, et al. Assessing the oxidative potential of PAHs in ambient PM 2.5 using the DTT consumption assay

[2] Abdul Hadi Mehmood, et al. The development of an endoplasmic reticulum-targeting fluorescent probe for the imaging of 1,4-dithiothreitol (DTT) in living cells

[3] Yiwen Wang, et al. Toxicity of Dithiothreitol (DTT) to Drosophila melanogaster

[4] Brittany C Hudson, et al. The effects of dithiothreitol (DTT) on fluorescent qPCR dyes

[5] Heng Zhou, et al. Oncolysis with DTT-205 and DTT-304 generates immunological memory in cured animals

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Keywords: DTT, DL-Dithiothreitol; Cleland’s reagent supplier, inhibitors, activators

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