Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM.
J Transl Med. 2023 Jan 13;21(1):24.
Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy
Mdivi-1 purchased from AbMole
J Transl Med. 2023 Jan 13;21(1):24.
Alamandine/MrgD axis prevents TGF-β1-mediated fbroblast activation via regulation of aerobic glycolysis and mitophagy
Mdivi-1 purchased from AbMole
J Agric Food Chem. 2023 Oct 4;71(39):14276-14288.
Folic Acid Protects against Ethanol-Induced Hepatic Mitophagy Imbalance by ROS Scavenging and Attenuating the Elevated Hcy Levels
Mdivi-1 purchased from AbMole
| Molecular Weight | 353.22 |
| Formula | C15H10Cl2N2O2S |
| CAS Number | 338967-87-6 |
| Solubility (25°C) | DMSO 55 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Lin Li, et al. Mdivi-1 alleviates atopic dermatitis through the inhibition of NLRP3 inflammasome
[3] Barbara Koch, et al. Mdivi-1 and mitochondrial fission: recent insights from fungal pathogens
[4] George Smith, et al. To mdivi-1 or not to mdivi-1: Is that the question?
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| Bis-T-23
Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. |
| DRP1i27 dihydrochloride
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| Dynole 34-2
Dynole 34-2 is a dynamin GTPase inhibitor (IC50s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME). |
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