EDTA disodium

Biological Activity

EDTA disodium is a chelating agent; sequesters di- and trivalent metal ions.

Product Citations

• 

  Cancer Res Commun. 2022 Aug.

  Pharmacological inhibition of SHP2 blocks both PI3K and MEK signaling in low-epiregulin HNSCC via GAB1
  EDTA disodium purchased from AbMole

• 

  Cell Death Differ. 2022 Jul;29(7):1395-1408.

  SARS-CoV-2 membrane protein causes the mitochondrial apoptosis and pulmonary edema via targeting BOK
  EDTA disodium purchased from AbMole

• 

  J Cell Mol Med. 2022 Jul;26(14):4048-4060.

  BRAF V600E protect from cell death via inhibition of the mitochondrial permeability transition in papillary and anaplastic thyroid cancers
  EDTA disodium purchased from AbMole

• 

  Cell Commun Signal. 2022 Jul 7;20(1):102.

  Circular dorsal ruffles disturb the growth factor-induced PI3K-AKT pathway in hepatocellular carcinoma Hep3B cells
  EDTA disodium purchased from AbMole

Chemical Information

Molecular Weight	372.23
Formula	C10H14N2Na2O8.2(H2O)
CAS Number	6381-92-6
Solubility (25°C)	Water 50 mg/mL
Storage	2-8°C, dry, sealed

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] S J Hepziba Magie Jessima, et al. Corrosion mitigation performance of disodium EDTA functionalized chitosan biomacromolecule - Experimental and theoretical approach

[2] Alessandro Fulgenzi, et al. EDTA Chelation Therapy for the Treatment of Neurotoxicity

[3] Virginia M Weaver, et al. Does calcium disodium EDTA slow CKD progression?

[4] Rebecca S Lanigan, et al. Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA