EDTA disodium is a chelating agent; sequesters di- and trivalent metal ions.
Cancer Res Commun. 2022 Aug.
Pharmacological inhibition of SHP2 blocks both PI3K and MEK signaling in low-epiregulin HNSCC via GAB1
EDTA disodium purchased from AbMole
Cell Death Differ. 2022 Jul;29(7):1395-1408.
SARS-CoV-2 membrane protein causes the mitochondrial apoptosis and pulmonary edema via targeting BOK
EDTA disodium purchased from AbMole
J Cell Mol Med. 2022 Jul;26(14):4048-4060.
BRAF V600E protect from cell death via inhibition of the mitochondrial permeability transition in papillary and anaplastic thyroid cancers
EDTA disodium purchased from AbMole
Cell Commun Signal. 2022 Jul 7;20(1):102.
Circular dorsal ruffles disturb the growth factor-induced PI3K-AKT pathway in hepatocellular carcinoma Hep3B cells
EDTA disodium purchased from AbMole
| Molecular Weight | 372.23 |
| Formula | C10H14N2Na2O8.2(H2O) |
| CAS Number | 6381-92-6 |
| Solubility (25°C) | Water 50 mg/mL |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Alessandro Fulgenzi, et al. EDTA Chelation Therapy for the Treatment of Neurotoxicity
[3] Virginia M Weaver, et al. Does calcium disodium EDTA slow CKD progression?
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