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EDTA disodium

Cat. No. M9878
EDTA disodium Structure
Size Price Availability Quantity
10g USD 20  USD20 In stock
50g USD 40  USD40 In stock
100g USD 55  USD55 In stock
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Quality Control & Documentation
Biological Activity

EDTA disodium is a chelating agent; sequesters di- and trivalent metal ions.

Product Citations
Chemical Information
Molecular Weight 372.23
Formula C10H14N2Na2O8.2(H2O)
CAS Number 6381-92-6
Solubility (25°C) Water 50 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] S J Hepziba Magie Jessima, et al. Corrosion mitigation performance of disodium EDTA functionalized chitosan biomacromolecule - Experimental and theoretical approach

[2] Alessandro Fulgenzi, et al. EDTA Chelation Therapy for the Treatment of Neurotoxicity

[3] Virginia M Weaver, et al. Does calcium disodium EDTA slow CKD progression?

[4] Rebecca S Lanigan, et al. Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA

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