All AbMole products are for research use only, cannot be used for human consumption.
GW4869 (GW69A, GW554869A) is a noncompetitive inhibitor of neutral Smase (spspingolipase) with IC50 of 1 μM. GW4869 is selective for N-smase and has no inhibitory effect on acidic SMase at concentrations up to 150 μm. GW4869 is also an inhibitor of exosome synthesis/release. LPS-triggered exosome generation was remarkably attenuated in macrophages upon pre-treatment of macrophages with 10 μM GW4869, as evidenced by a 22% reduction in the activity of AChE. Such attenuation was further enhanced by treatment with 20 μM GW4869. GW4869 prevented CLP-induced diaphragm calpain activation and diaphragm weakness in mice.
Int J Biol Sci. 2023 Sep 4;19(15):4744-4762.
Hypoxia-induced exosomes facilitate lung pre-metastatic niche formation in hepatocellular carcinoma through the miR-4508-RFX1-IL17A-p38 MAPK-NF-κB pathway
GW4869 2HCl purchased from AbMole
Int Immunopharmacol. 2023 Nov 27;126:111301.
Inhibition of circulating exosomes release with GW4869 mitigates severe acute pancreatitis-stimulated intestinal barrier damage through suppressing NLRP3 inflammasome-mediated pyroptosis
GW4869 2HCl purchased from AbMole
Cell Death Dis. 2021 Aug 27;12(9):815.
Extracellular vesicles package dsDNA to aggravate Crohn’s disease by activating the STING pathway
GW4869 2HCl purchased from AbMole
| Molecular Weight | 577.50 |
| Formula | C30H30Cl2N6O2 |
| CAS Number | 6823-69-4 |
| Solubility (25°C) | DMSO 1 mg/mL (Need ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Phospholipase Products |
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ML298 is a potent and selective inhibitor of Phospholipase D2 (PLD2) with an IC50 of 355 nM. |
| LCL521
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| SPK-601
SPK-601 (LMV-601) is an inhibitor of the phosphatidylcholine-specific phospholipase C (PC-PLC). |
| CCT129957
CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of ~3 μM and a GC50 of 15 μM. |
| ONO-RS-082
ONO-RS-082 is an inhibitor of phospholipase A (PLA). |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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