Certificate of Analysis
| Product Name: | GW4869 2HCl |
| Catalog Number: | M4974 |
| CAS Number: | 6823-69-4 |
Physical and Chemical Properties
| Formula: | C30H30Cl2N6O2 |
| Molecular Weight: | 577.50 |
| Solubility: | DMSO 1 mg/mL (Need ultrasonic) |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.87% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | GW4869 (GW69A, GW554869A) is a noncompetitive inhibitor of neutral Smase (spspingolipase) with IC50 of 1 μM. GW4869 is also an inhibitor of exosome biogenesis/release, followed by endotoxin (LPS) challenge. GW4869 could effectively inhibit the generation of exosomes in macrophages and in vivo. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |