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Polydatin

Cat. No. M3969

All AbMole products are for research use only, cannot be used for human consumption.

Polydatin Structure
Synonym:

Piceid

Size Price Availability Quantity
10mM*1mL in DMSO USD 45  USD45 In stock
50mg USD 41  USD41 In stock
100mg USD 68  USD68 In stock
200mg USD 98  USD98 In stock
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Quality Control & Documentation
Biological Activity

Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest. Polydatin has been shown to inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. Endothelial cell studies report that Polydatin can inhibit ICAM-1 expression, elevate Ca2+, weaken white blood cell-endothelial cell adhesion, and activate KATP channels. In the present study, polydatin protects NRK-52E cells from I/R injury possibly by relieving the inflammatory response through regulation of TLR4/NF-κB signaling pathway. Polydatin regulates glucose and lipid metabolism in experimental diabetic models, the underlying mechanism is probably associated with regulating the Akt pathway. The effect of polydatin on increased Akt phosphorylation is independent of prompting insulin secretion, but dependent of increasing IRS phosphorylation.

Product Citations
Chemical Information
Molecular Weight 390.40
Formula C20H22O8
CAS Number 27208-80-6
Solubility (25°C) DMSO ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hui-Lin Wang, et al. Fundam Clin Pharmacol . Synergistic effects of polydatin and vitamin C in inhibiting cardiotoxicity induced by doxorubicin in rats

[2] Kang-Feng Jiang, et al. Acta Pharmacol Sin . Polydatin ameliorates Staphylococcus aureus-induced mastitis in mice via inhibiting TLR2-mediated activation of the p38 MAPK/NF-κB pathway

[3] Lou T, et al. Inflammation. Inhibitory Effects of Polydatin on Lipopolysaccharide-Stimulated RAW 264.7 Cells.

[4] Li Y, et al. Zhongguo Zhong Yao Za Zhi. [Inhibitory effect of polydatin on expression of toll-like receptor 4 in ischemia-reperfusion injured NRK-52E cells].

[5] Hao J, et al. Eur J Pharmacol. Polydatin improves glucose and lipid metabolism in experimental diabetes through activating the Akt signaling pathway.

[6] Zhang Y, et al. Oncol Lett. Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest.

[7] Xiao-hui Li, et al. Mediators Inflamm. Protective effects of polydatin on septic lung injury in mice via upregulation of HO-1

[8] Ravagnan G, et al. Inflammation. Polydatin, a natural precursor of resveratrol, induces β-defensin production and reduces inflammatory response.

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Keywords: Polydatin, Piceid supplier, Phospholipase, inhibitors, activators

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