Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest.Polydatin has been shown to inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C.Endothelial cell studies report that Polydatin can inhibit ICAM-1 expression, elevate Ca2+, weaken white blood cell-endothelial cell adhesion, and activate KATP channels.In the present study, polydatin protects NRK-52E cells from I/R injury possibly by relieving the inflammatory response through regulation of TLR4/NF-κB signaling pathway.polydatin regulates glucose and lipid metabolism in experimental diabetic models, the underlying mechanism is probably associated with regulating the Akt pathway. The effect of polydatin on increased Akt phosphorylation is independent of prompting insulin secretion, but dependent of increasing IRS phosphorylation.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 60 mg/mL|
Inhibitory Effects of Polydatin on Lipopolysaccharide-Stimulated RAW 264.7 Cells.
Lou T, et al. Inflammation. 2015 Jan 8. PMID: 25567371.
[Inhibitory effect of polydatin on expression of toll-like receptor 4 in ischemia-reperfusion injured NRK-52E cells].
Li Y, et al. Zhongguo Zhong Yao Za Zhi. 2014 Aug;39(16):3157-61. PMID: 25509306.
Polydatin improves glucose and lipid metabolism in experimental diabetes through activating the Akt signaling pathway.
Hao J, et al. Eur J Pharmacol. 2014 Dec 15;745:152-65. PMID: 25310908.
Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest.
Zhang Y, et al. Oncol Lett. 2014 Jan;7(1):295-301. PMID: 24348867.
Protective effects of polydatin on septic lung injury in mice via upregulation of HO-1
Xiao-hui Li, et al. Mediators Inflamm. 2013;2013:354087. PMID: 23431240.
Polydatin, a natural precursor of resveratrol, induces β-defensin production and reduces inflammatory response.
Ravagnan G, et al. Inflammation. 2013 Feb;36(1):26-34. PMID: 22956122.
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