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Polydatin

Cat. No. M3969
Polydatin Structure
Synonym:

Piceid

Size Price Availability Quantity
50mg USD 50  USD50 In stock
100mg USD 80  USD80 In stock
200mg USD 115  USD115 In stock
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Quality Control & Documentation
Biological Activity

Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest.Polydatin has been shown to inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C.Endothelial cell studies report that Polydatin can inhibit ICAM-1 expression, elevate Ca2+, weaken white blood cell-endothelial cell adhesion, and activate KATP channels.In the present study, polydatin protects NRK-52E cells from I/R injury possibly by relieving the inflammatory response through regulation of TLR4/NF-κB signaling pathway.polydatin regulates glucose and lipid metabolism in experimental diabetic models, the underlying mechanism is probably associated with regulating the Akt pathway. The effect of polydatin on increased Akt phosphorylation is independent of prompting insulin secretion, but dependent of increasing IRS phosphorylation.

Chemical Information
Molecular Weight 390.40
Formula C20H22O8
CAS Number 27208-80-6
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hui-Lin Wang, et al. Fundam Clin Pharmacol . Synergistic effects of polydatin and vitamin C in inhibiting cardiotoxicity induced by doxorubicin in rats

[2] Kang-Feng Jiang, et al. Acta Pharmacol Sin . Polydatin ameliorates Staphylococcus aureus-induced mastitis in mice via inhibiting TLR2-mediated activation of the p38 MAPK/NF-κB pathway

[3] Lou T, et al. Inflammation. Inhibitory Effects of Polydatin on Lipopolysaccharide-Stimulated RAW 264.7 Cells.

[4] Li Y, et al. Zhongguo Zhong Yao Za Zhi. [Inhibitory effect of polydatin on expression of toll-like receptor 4 in ischemia-reperfusion injured NRK-52E cells].

[5] Hao J, et al. Eur J Pharmacol. Polydatin improves glucose and lipid metabolism in experimental diabetes through activating the Akt signaling pathway.

[6] Zhang Y, et al. Oncol Lett. Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest.

[7] Xiao-hui Li, et al. Mediators Inflamm. Protective effects of polydatin on septic lung injury in mice via upregulation of HO-1

[8] Ravagnan G, et al. Inflammation. Polydatin, a natural precursor of resveratrol, induces β-defensin production and reduces inflammatory response.

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Keywords: Polydatin, Piceid supplier, Phospholipase, inhibitors, activators


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