| Cat.No. | Name | Information |
|---|---|---|
| M6074 | AA26-9 | AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. AA26-9 targets included serine peptidases, lipases, amidases, esterases, and thioesterases. |
| M4974 | GW4869 2HCl | GW4869 (GW69A, GW554869A) is a noncompetitive inhibitor of neutral Smase (spspingolipase) with IC50 of 1 μM. GW4869 is also an inhibitor of exosome biogenesis/release, followed by endotoxin (LPS) challenge. GW4869 could effectively inhibit the generation of exosomes in macrophages and in vivo. |
| M56769 | Vinaxanthone | Vinaxanthone (SM-345431) is a potent and selective semaphorin3A, phospholipase C (PLC) and FabI inhibitor, with IC50s of 0.1-0.2 μM and 0.9 mM for semaphorin3A and FabI. |
| M52550 | Phospholipase A2 | Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA). |
| M49432 | Melittin | Melittin is a PLA2 activator that stimulates the activity of low molecular weight PLA2 without increasing the activity of high molecular weight PLA2. |
| M29963 | DPTIP | DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM. |
| M21681 | Compound 48/80 trihydrochloride | Compound 48/80 trihydrochloride is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways. |
| M21360 | (E/Z)-Polydatin | (E/Z)-Polydatin (E/Z)-Piceid) is a single-crystal compound originally isolated from the roots and rhizomes of Echinacea purpurea with antiplatelet aggregation, anti-low density lipoprotein (LDL) oxidation, cardioprotective, anti-inflammatory and immunomodulatory properties. |
| M18276 | 1-Naphthaleneacetic acid | 1-Naphthaleneacetic acid is a auxin which can promote plant growth. 1-Naphthaleneacetic acid is also an inhibitor of PLA2, with an IC50 of 13.16 μM. |
| M14514 | N-(p-amylcinnamoyl) Anthranilic Acid | N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker. |
| M14513 | Melittin TFA | Melittin TFA is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2. |
| M14511 | LEI-401 | LEI-401 is a first-in-class, selective, and CNS-active NAPE-PLD (N-acylphosphatidylethanolamine phospholipase D) inhibitor, with an IC50 of 27 nM. |
| M14510 | D609 | D609 is a selective competitive inhibitor of phosphatidyl choline-specific phospholipase C (PC-PLC), with Ki of 6.4 μM. |
| M14509 | CAY10650 | CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion. |
| M14508 | 3-Nitrocoumarin | 3-Nitrocoumarin (3-NC) is a potent and selective Phospholipase C-γ (PLC-γ) inhibitor. |
| M8927 | VU-0155069 | VU-0155069 is a potent and selective phospholipase D1 (PLD1) inhibitor. |
| M8168 | sPLA2 inhibitor | Secretory phospholipase A2 inhibitor blocks the activation of NF-κB, Akt, p38 MAPK and ERK pathways. |
| M7440 | U 73343 | U 73343 is a analog of U 73122. |
| M6979 | ML348 | ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM. |
| M5855 | Rilapladib | Rilapladib (SB 659032) is a selective Lp-PLA2 (lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 230 pM. Rilapladib (SB 659032) is also a PAFR (Platelet Activating Factor Receptor) antagonist. |
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