Cat.No. | Name | Information |
---|---|---|
M6074 | AA26-9 | AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. AA26-9 targets included serine peptidases, lipases, amidases, esterases, and thioesterases. |
M4974 | GW4869 2HCl | GW4869 (GW69A, GW554869A) is a noncompetitive inhibitor of neutral Smase (spspingolipase) with IC50 of 1 μM. GW4869 is also an inhibitor of exosome biogenesis/release, followed by endotoxin (LPS) challenge. GW4869 could effectively inhibit the generation of exosomes in macrophages and in vivo. |
M49432 | Melittin | Melittin is a PLA2 activator that stimulates the activity of low molecular weight PLA2 without increasing the activity of high molecular weight PLA2. |
M29963 | DPTIP | DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM. |
M21681 | Compound 48/80 trihydrochloride | Compound 48/80 trihydrochloride is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways. |
M21360 | (E/Z)-Polydatin | (E/Z)-Polydatin (E/Z)-Piceid) is a single-crystal compound originally isolated from the roots and rhizomes of Echinacea purpurea with antiplatelet aggregation, anti-low density lipoprotein (LDL) oxidation, cardioprotective, anti-inflammatory and immunomodulatory properties. |
M18276 | 1-Naphthaleneacetic acid | 1-Naphthaleneacetic acid is a auxin which can promote plant growth. 1-Naphthaleneacetic acid is also an inhibitor of PLA2, with an IC50 of 13.16 μM. |
M14513 | Melittin TFA | Melittin TFA is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2. |
M14511 | LEI-401 | LEI-401 is a first-in-class, selective, and CNS-active NAPE-PLD (N-acylphosphatidylethanolamine phospholipase D) inhibitor, with an IC50 of 27 nM. |
M14510 | D609 | D609 is a selective competitive inhibitor of phosphatidyl choline-specific phospholipase C (PC-PLC), with Ki of 6.4 μM. |
M14509 | CAY10650 | CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion. |
M14508 | 3-Nitrocoumarin | 3-Nitrocoumarin (3-NC) is a potent and selective Phospholipase C-γ (PLC-γ) inhibitor. |
M8927 | VU-0155069 | VU-0155069 is a potent and selective phospholipase D1 (PLD1) inhibitor. |
M8168 | sPLA2 inhibitor | Secretory phospholipase A2 inhibitor blocks the activation of NF-κB, Akt, p38 MAPK and ERK pathways. |
M7591 | Arachidonyl trifluoromethyl ketone | Inhibits anandamide hydrolysis in vitro; inhibits phospholipase A2. |
M7440 | U 73343 | U 73343 is a analog of U 73122. |
M5201 | FIPI | FIPI inhibited both PLD1 and PLD2 in a dose-dependent manner, with 50% loss of activity observed at approximately 25 nM. |
M5170 | U73122 | U73122 is a potent inhibitor of phospholipase C, phospholipase A2 and 5-LO (5-lipoxygenase). |
M4144 | Tanshinone-I | Tanshinone-I |
M3969 | Polydatin | Polydatin is a monocrystaline compound isolated from Polygonum cuspidatum Sieb. et Zucc. (Polygonaceae) with biological properties, such as anti-inflammation, anti-oxidative and nephroprotective effects. |
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