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CAY10650

Cat. No. M14509
CAY10650 Structure
Size Price Availability Quantity
5mg USD 190  USD190 In stock
10mg USD 330  USD330 In stock
25mg USD 730  USD730 In stock
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Quality Control & Documentation
Biological Activity

CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion.

Chemical Information
Molecular Weight 471.5
CAS Number 1233706-88-1
Solubility (25°C) DMSO ≥ 43 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Cheng-Zhe Wu, et al. NOX4/Src regulates ANP secretion through activating ERK1/2 and Akt/GATA4 signaling in beating rat hypoxic atria

[2] Mauro Valentino Paloschi, et al. Cytosolic phospholipase A 2-α participates in lipid body formation and PGE 2 release in human neutrophils stimulated with an L-amino acid oxidase from Calloselasma rhodostoma venom

[3] Trivendra Tripathi, et al. Role of phospholipase A₂ (PLA₂) inhibitors in attenuating apoptosis of the corneal epithelial cells and mitigation of Acanthamoeba keratitis

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Keywords: CAY10650 supplier, Phospholipase, inhibitors, activators


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