All AbMole products are for research use only, cannot be used for human consumption.
Compound 48/80 trihydrochloride is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets.
| Molecular Weight | 629.10 |
| Formula | C32H48Cl3N3O3 |
| CAS Number | 848035-21-2 |
| Solubility (25°C) | Water 25 mg/mL (Need ultrasonic) |
| Storage | 4°C, dry, sealed |
| Related Phospholipase Products |
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| ML-298
ML298 is a potent and selective inhibitor of Phospholipase D2 (PLD2) with an IC50 of 355 nM. |
| LCL521
LCL521 is an acid ceramidase (ACDase) inhibitor. |
| SPK-601
SPK-601 (LMV-601) is an inhibitor of the phosphatidylcholine-specific phospholipase C (PC-PLC). |
| CCT129957
CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of ~3 μM and a GC50 of 15 μM. |
| ONO-RS-082
ONO-RS-082 is an inhibitor of phospholipase A (PLA). |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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