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(E/Z)-Polydatin

Cat. No. M21360
(E/Z)-Polydatin Structure
Synonym:

(E/Z)-Piceid

Size Price Availability Quantity
500mg USD 48  USD48 In stock
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Quality Control & Documentation
Biological Activity

(E/Z)-Polydatin (E/Z)-Piceid) is a single-crystal compound originally isolated from the roots and rhizomes of Echinacea purpurea with antiplatelet aggregation, anti-low density lipoprotein (LDL) oxidation, cardioprotective, anti-inflammatory and immunomodulatory properties.

Chemical Information
Molecular Weight 390.38
Formula C20H22O8
CAS Number 65914-17-2
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Alison D Pawlus, et al. J Agric Food Chem. Stilbenoid profiles of canes from Vitis and Muscadinia species

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Keywords: (E/Z)-Polydatin, (E/Z)-Piceid supplier, Phospholipase, inhibitors, activators


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