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MTT

Cat. No. M7007
MTT Structure
Synonym:

Thiazolyl Blue; Thiazolyl Blue Tetrazolium Bromide; Methylthiazolyldiphenyl-tetrazolium bromide

Size Price Availability Quantity
500mg USD 42.3  USD47 In stock
1g USD 63  USD70 In stock
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Quality Control
Biological Activity

MTT is a reagent used in the measurement of cell proliferation.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 414.32
Formula C18H16N5SBr
CAS Number 298-93-1
Purity >99%
Solubility Water 4.2 mg/mL
Storage 2-8°C, dry, protect from light, sealed
References

Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.
Pfefferkorn, et al. J Med Chem. 2012;55: 1318. PMID: 22196621.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: MTT, Thiazolyl Blue; Thiazolyl Blue Tetrazolium Bromide; Methylthiazolyldiphenyl-tetrazolium bromide supplier, Fluorescent Dye, inhibitors

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