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MTT

Cat. No. M7007
MTT Structure
Synonym:

Thiazolyl Blue; Thiazolyl Blue Tetrazolium Bromide; Methylthiazolyldiphenyl-tetrazolium bromide

Size Price Availability Quantity
500mg USD 47  USD47 In stock
1g USD 70  USD70 In stock
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Quality Control & Documentation
Biological Activity

MTT is a reagent used in the measurement of cell proliferation.

Product Citations
Chemical Information
Molecular Weight 414.32
Formula C18H16N5SBr
CAS Number 298-93-1
Solubility (25°C) Water 4.2 mg/mL
Storage 2-8°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Priti Kumar, et al. Cold Spring Harb Protoc . Analysis of Cell Viability by the MTT Assay

[2] Pfefferkorn, et al. J Med Chem. Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.

[3] Johan van Meerloo, et al. Methods Mol Biol . Cell sensitivity assays: the MTT assay

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Keywords: MTT, Thiazolyl Blue; Thiazolyl Blue Tetrazolium Bromide; Methylthiazolyldiphenyl-tetrazolium bromide supplier, Fluorescent Dye, inhibitors, activators

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