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2-Deoxy-D-glucose

Cat. No. M5140

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2-Deoxy-D-glucose Structure
Synonym:

2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
500mg USD 40  USD40 In stock
1g USD 50  USD50 In stock
5g USD 150  USD150 In stock
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Biological Activity

2-Deoxy-D-Glucose (2-DG) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which cannot be further metabolized by phosphoglucose isomerase. Most tumor cells showed higher DG uptake and 3-O-MG transport than the human fibroblast cells. The 2DG6P content in isolated rat soleus muscle after incubation with 2-deoxyglucose (2DG) was increased in a dose-dependent manner by insulin (ED(50) = 0.6 mU/ml), the maximum response being about 5 times that of the basal content in vitro. 2-DG increased mitochondrial dysfunction and upregulated Bax/Bcl-2, promoting cytochrome c release to initiate procaspase 3 cleavage induced by buforin IIb.

2-DG plus BCNU significantly suppressed tumor growth with lower side effects compared with BCNU alone in tumor-bearing mice. 2-DG also exerts anticonvulsant effects in vivo against perforant path kindling in rats. Rats fed the 2-DG diet exhibited significant reductions in resting BP, attenuated BP responses during stress, and accelerated recovery to baseline after stress. Plasma concentrations of ACTH and corticosterone were elevated under nonstress conditions in rats fed the 2-DG diet and exhibited differential responses to single (enhanced response) and multiple (reduced response) stress sessions compared with rats fed control rat chow ad libitum. The 2-DG diet improved glucose metabolism, as indicated by decreased concentrations of blood glucose and insulin under nonstress conditions, but glucose and insulin responses to stress were maintained.

Product Citations
Chemical Information
Molecular Weight 164.16
Formula C6H12O5
CAS Number 154-17-6
Solubility (25°C) Water 30 mg/mL
DMSO 15 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ueyama A,et.al. Biol Signals Recept Nonradioisotope assay of glucose uptake activity in rat skeletal muscle using enzymatic measurement of 2-deoxyglucose 6-phosphate in vitro and in vivo.

[2] Waki A,et.al. Nucl Med Biol The importance of glucose transport activity as the rate-limiting step of 2-deoxyglucose uptake in tumor cells in vitro.

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Keywords: 2-Deoxy-D-glucose, 2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose supplier, Cell Culture, inhibitors, activators

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