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Cat. No. M3422
Capsaicin Structure

Qutenza, Vanilloid

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50mg USD 60  USD60 In stock
100mg USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

Capsaicin is an active component of chili peppers, which are plants belonging to the genus Capsicum. The burning and painful sensations associated with capsaicin result from its chemical interaction with sensory neurons. Capsaicin, as a member of the vanilloid family, binds to a receptor called the vanilloid receptor subtype 1 (VR1). By binding to the VR1 receptor, the capsaicin molecule produces the same sensation that excessive heat or abrasive damage would cause, explaining why the spiciness of capsaicin is described as a burning sensation.

Product Citations
Chemical Information
Molecular Weight 305.41
Formula C18H27NO3
CAS Number 404-86-4
Solubility (25°C) DMSO 40 mg/mL
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Wytske Fokkens, et al. Capsaicin for Rhinitis

[2] Angela M Chapa-Oliver, et al. Capsaicin: From Plants to a Cancer-Suppressing Agent

[3] Ruth Clark, et al. Anticancer Properties of Capsaicin Against Human Cancer

[4] Krishnapura Srinivasan. Biological Activities of Red Pepper (Capsicum annuum) and Its Pungent Principle Capsaicin: A Review

[5] Surinder Kumar Sharma, et al. Mechanisms and clinical uses of capsaicin

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Keywords: Capsaicin, Qutenza, Vanilloid supplier, TRP Channel, inhibitors, activators

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