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TRP Channel Transient Receptor Potential Channel

Inhibitors

Cat.No.  Name Information
M11223 TRPM4-IN-1 Trpm4-in-1 (CBA) is an effective and selective cationic channel TRPM4 inhibitor with an IC50 of 1.5 μM.
M10927 GFB-8438 GFB-8438 is a potent subtype selective TRPC5 inhibitor against hTRPC5 and hTRPC4 IC50 0.18 and 0.29 μM, respectively. GFB-8438 has good selectivity for TRPC6, other members of the TRP family, NaV1.5, and limited activity against hERG channels. Protective effect of GFB-8438 on mouse podocytes.
M10841 Mavatrep Mavatrep is an orally active TRPV1 antagonist with high affinity for the hTRPV1 channel, inhibits the binding of the TRPV1 agonist to [3H]-Resiniferatoxin (Ki=6.5 nM), and has a low effect on the enzymatic activity of CYP subtypes 3A4, 1A2, and 2D6.
M10840 JNJ-17203212 JNJ-17203212 is a selective, highly effective, competitive TRPV1 antagonist. JNJ-17203212 was developed for research on pain management, such as migraines.
M10783 Asivatrep Asivatrep (PAC-14028) is a highly selective transient receptor potential vanilla acid subtype 1 (TRPV1) antagonist.
M10625 GSK2193874 GSK2193874 is a first-in-class orally bioavailable potent antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist with IC50 values of 2, 5, and 40 nM. GSK2193874 is the first-in-class orally bioavailable TRPV4 inhibitor that demonstrated ability to improve pulmonary functions in a number of heart failure models.
M10588 Methyl syringate Methyl syringate (Syringic Acid Methyl Ester), a plant phenolic compound, is a specific and selective TRPA1 agonist.
M10493 MDR-652 MDR-652 is a potent and specific transient receptor potential vanilloid 1 (TRPV1) agonist with Ki of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1, respectively.
M10318 AC1903 AC1903 is a specific inhibitor of TRPC5 channel.
M10315 MK6-83 MK6-83 is an agonist of the transient receptor potential channel ML3 (TRPML3).
M9962 Nonivamide Nonivamide (also called pelargonic acid vanillylamide or PAVA) can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.
M8239 HC-067047 HC-067047 is a potent, selective inhibitor of hTRPV4.
M7698 Capsazepine Capsazepine is a specific vanilloid receptor antagonist; synthetic analog of capsaicin.
M7303 SKF 96365 hydrochloride SKF 96365 hydrochloride is a tRPC channel blocker; also inhibits store-operated Ca2+ entry.
M6983 ML SA1 ML SA1 is a activator of TRPML channels.
M6705 EIPA EIPA is a inhibits TRPP3-mediated currents; also inhibits the Na +/H + exchanger (NHE).
M6494 BCTC BCTC is a tRPV1 antagonist. BCTC is also a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells.
M5349 (+)-Camphor Camphor is a waxy, flammable, white or transparent solid with a strong aroma, often used to relieve pain, reduce itching and treat fungal infections. It can activate TRPV1 and TRPV3.
M5154 Diphenyleneiodonium chloride Diphenyleneiodonium chloride (DPI) is an irreversible inhibitor of iNOS and eNOS with IC50 values of 50 nM and 0.3 µM, respectively.
M4513 Dihydrocapsaicin Dihydrocapsaicin is a natural capsaicin that is a selective TRPV1 agonist and increases P-Akt levels. Dihydrocapsaicin can enhance hypothermic induced neuroprotection.



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