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Capsazepine

Cat. No. M7698
Capsazepine Structure
Size Price Availability Quantity
10mg USD 89  USD89 In stock
25mg USD 200  USD200 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Capsazepine is a specific vanilloid receptor antagonist; synthetic analog of capsaicin.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 376.9
Formula C19H21ClN2O2S
CAS Number 138977-28-3
Purity >99%
Solubility DMSO 40 mg/mL
Storage at -20°C
References

[1] Darine Fakih, et al. Capsazepine decreases corneal pain syndrome in severe dry eye disease

[2] Min Hee Yang, et al. Pleiotropic Pharmacological Actions of Capsazepine, a Synthetic Analogue of Capsaicin, against Various Cancers and Inflammatory Diseases

[3] Danilo De Gregorio, et al. Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain

[4] Guang-Feng Zuo, et al. Capsazepine concentration dependently inhibits currents in HEK 293 cells mediated by human hyperpolarization-activated cyclic nucleotide-gated 2 and 4 channels

[5] Hsiu-Peng Teng, et al. Capsazepine elevates intracellular Ca2+ in human osteosarcoma cells, questioning its selectivity as a vanilloid receptor antagonist

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Capsazepine supplier, TRP Channel, inhibitors

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