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Capsazepine

Cat. No. M7698
Capsazepine Structure
Size Price Availability Quantity
10mg USD 89  USD89 In stock
25mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Capsazepine is a specific vanilloid receptor antagonist; synthetic analog of capsaicin.

Product Citations
Chemical Information
Molecular Weight 376.9
Formula C19H21ClN2O2S
CAS Number 138977-28-3
Solubility (25°C) DMSO 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Darine Fakih, et al. Capsazepine decreases corneal pain syndrome in severe dry eye disease

[2] Min Hee Yang, et al. Pleiotropic Pharmacological Actions of Capsazepine, a Synthetic Analogue of Capsaicin, against Various Cancers and Inflammatory Diseases

[3] Danilo De Gregorio, et al. Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain

[4] Guang-Feng Zuo, et al. Capsazepine concentration dependently inhibits currents in HEK 293 cells mediated by human hyperpolarization-activated cyclic nucleotide-gated 2 and 4 channels

[5] Hsiu-Peng Teng, et al. Capsazepine elevates intracellular Ca2+ in human osteosarcoma cells, questioning its selectivity as a vanilloid receptor antagonist

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