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MK6-83

Cat. No. M10315
MK6-83 Structure
Synonym:

MK683

Size Price Availability Quantity
10mg USD 108  USD108 In stock
25mg USD 220  USD220 In stock
50mg USD 372  USD372 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

MK6-83 is an agonist of the transient receptor potential channel ML3 (TRPML3). MK6-83 appears to be significantly more efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells than on those isolated from TRPML1-/- cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 336.46
Formula C16H20N2O2S2
CAS Number 1062271-24-2
Purity >99%
Solubility DMSO 4 mg/mL
Storage at -20°C
References

[1] Cheng-Chang Chen, et al. Nat Commun. A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV

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Keywords: MK6-83, MK683 supplier, TRP Channel, inhibitors

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