TRP Channel Transient Receptor Potential Channel

Inhibitors

Cat.No.	Name	Information
M6494	BCTC	BCTC is a tRPV1 antagonist. BCTC is also a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells.
M7698	Capsazepine	Capsazepine is a specific vanilloid receptor antagonist; synthetic analog of capsaicin.
M10315	MK6-83	MK6-83 is an agonist of the transient receptor potential channel ML3 (TRPML3).
M9962	Nonivamide	Nonivamide (also called pelargonic acid vanillylamide or PAVA) can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.
M2960	Probenecid	Probenecid is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16.
M7603	AP-18	AP-18 is a selective TRPA1 channel blocker. AP-18 blocks activation of TRPA1 by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively.
M7387	TCS 5861528	TCS 5861528 (Chembridge-5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 μM and 18.7 μM, respectively.
M7303	SKF 96365 hydrochloride	SKF-96365 hydrochloride is a potent TRP channel blocker and SOCE (store-operated Ca2+ entry) inhibitor. It also induces cell cycle arrest and apoptosis in colorectal cancer cells.
M7264	SB 366791	SB 366791 is a potent, selective, competitive TRPV1 antagonist.
M6983	ML SA1	ML SA1 is a activator of TRPML channels.
M6741	Gadolinium chloride	Gadolinium chloride is a stretch-activated calcium channel blocker; calcium-sensing receptor agonist.
M6705	EIPA	EIPA is a inhibits TRPP3-mediated currents; also inhibits the Na ⁺/H ⁺ exchanger (NHE).
M6494	BCTC	BCTC is a tRPV1 antagonist. BCTC is also a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells.
M6470	ASP7663	ASP7663 is an orally active and selective TRPA1 agonist.
M5349	(+)-Camphor	Camphor is a waxy, flammable, white or transparent solid with a strong aroma, often used to relieve pain, reduce itching and treat fungal infections. It can activate TRPV1 and TRPV3.
M4513	Dihydrocapsaicin	Dihydrocapsaicin is a natural capsaicin that is a selective TRPV1 agonist and increases P-Akt levels. Dihydrocapsaicin can enhance hypothermic induced neuroprotection.
M4122	8-Gingerol	8-gingerol is derived from the rhizome of ginger (Z. officinale). It has oral activity and can activate TRPV1 with EC50 of 5.0 µM. 8-Gingerol inhibited COX-2 and h. pylori growth in vitro.
M3187	Optovin	Optovin is a reversible photoactivated TRPA1 activator. Optovin activates TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues.
M2960	Probenecid	Probenecid is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16.
M2591	Icilin	Icilin is a synthetic super-agonist of the transient receptor potential M8 (TRPM8) ion channel.
M2383	AMG-517	AMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM.
M2087	HC-030031	HC-030031 is a selective TRPA1 blocker, antagonizing TRPA1-mediated calcium influx induced by AITC and formalin (IC50 = 6.2 and 5.3 μM, respectively).
M1846	SB-705498	SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1.

Signaling Pathways

Product Type

TRP Channel Transient Receptor Potential Channel

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