Inhibitors
Cat.No. | Name | Information |
---|---|---|
M6494 | BCTC | BCTC is a tRPV1 antagonist. BCTC is also a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. |
M7698 | Capsazepine | Capsazepine is a specific vanilloid receptor antagonist; synthetic analog of capsaicin. |
M10315 | MK6-83 | MK6-83 is an agonist of the transient receptor potential channel ML3 (TRPML3). |
M9962 | Nonivamide | Nonivamide (also called pelargonic acid vanillylamide or PAVA) can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A. |
M2960 | Probenecid | Probenecid is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. |
M7603 | AP-18 | AP-18 is a selective TRPA1 channel blocker. AP-18 blocks activation of TRPA1 by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. |
M7387 | TCS 5861528 | TCS 5861528 (Chembridge-5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 μM and 18.7 μM, respectively. |
M7303 | SKF 96365 hydrochloride | SKF-96365 hydrochloride is a potent TRP channel blocker and SOCE (store-operated Ca2+ entry) inhibitor. It also induces cell cycle arrest and apoptosis in colorectal cancer cells. |
M7264 | SB 366791 | SB 366791 is a potent, selective, competitive TRPV1 antagonist. |
M6983 | ML SA1 | ML SA1 is a activator of TRPML channels. |
M6741 | Gadolinium chloride | Gadolinium chloride is a stretch-activated calcium channel blocker; calcium-sensing receptor agonist. |
M6705 | EIPA | EIPA is a inhibits TRPP3-mediated currents; also inhibits the Na +/H + exchanger (NHE). |
M6494 | BCTC | BCTC is a tRPV1 antagonist. BCTC is also a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. |
M6470 | ASP7663 | ASP7663 is an orally active and selective TRPA1 agonist. |
M5349 | (+)-Camphor | Camphor is a waxy, flammable, white or transparent solid with a strong aroma, often used to relieve pain, reduce itching and treat fungal infections. It can activate TRPV1 and TRPV3. |
M4513 | Dihydrocapsaicin | Dihydrocapsaicin is a natural capsaicin that is a selective TRPV1 agonist and increases P-Akt levels. Dihydrocapsaicin can enhance hypothermic induced neuroprotection. |
M4122 | 8-Gingerol | 8-gingerol is derived from the rhizome of ginger (Z. officinale). It has oral activity and can activate TRPV1 with EC50 of 5.0 µM. 8-Gingerol inhibited COX-2 and h. pylori growth in vitro. |
M3187 | Optovin | Optovin is a reversible photoactivated TRPA1 activator. Optovin activates TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues. |
M2960 | Probenecid | Probenecid is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. |
M2591 | Icilin | Icilin is a synthetic super-agonist of the transient receptor potential M8 (TRPM8) ion channel. |
M2383 | AMG-517 | AMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM. |
M2087 | HC-030031 | HC-030031 is a selective TRPA1 blocker, antagonizing TRPA1-mediated calcium influx induced by AITC and formalin (IC50 = 6.2 and 5.3 μM, respectively). |
M1846 | SB-705498 | SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1. |
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