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Methyl syringate

Cat. No. M10588
Methyl syringate Structure
Synonym:

Syringic Acid Methyl Ester

Size Price Availability Quantity
100mg USD 50  USD50 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Methyl syringate (Syringic Acid Methyl Ester), a plant phenolic compound, is a specific and selective TRPA1 agonist.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 212.2
Formula C10H12O5
CAS Number 884-35-5
Purity >99%
Solubility DMSO ≥ 50 mg/mL
Storage at -20°C
References

[1] Joonwoo Park, et al. Phytomedicine. Methyl syringate, a TRPA1 agonist represses hypoxia-induced cyclooxygenase-2 in lung cancer cells

[2] Min Jung Kim, et al. PLoS One. The TRPA1 agonist, methyl syringate suppresses food intake and gastric emptying

[3] Hee Jin Son, et al. Arch Pharm Res. Methyl syringate, a low-molecular-weight phenolic ester, as an activator of the chemosensory ion channel TRPA1

[4] Tania Rosado, et al. Bioresour Technol. Methyl syringate: an efficient phenolic mediator for bacterial and fungal laccases

[5] Carlo I G Tuberoso, et al. J Agric Food Chem. Methyl syringate: a chemical marker of asphodel (Asphodelus microcarpus Salzm. et Viv.) monofloral honey

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Keywords: Methyl syringate, Syringic Acid Methyl Ester supplier, TRP Channel, inhibitors

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