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BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7.
| Molecular Weight | 442.43 |
| CAS Number | 2361241-23-6 |
| Solubility (25°C) | DMSO 31.25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Zhihuang Zheng, et al. Role of TRPC6 in kidney damage after acute ischemic kidney injury
[4] Pritesh P Jain, et al. TRPC6, a therapeutic target for pulmonary hypertension
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| 4-ONE
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